ArticleGene expression2006
Transcriptional profiling of the cell cycle checkpoint gene krüppel-like factor 4 reveals a global inhibitory function in macromolecular biosynthesis.
Article in Gene expression, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Review
- Acetylation of Checkpoint suppressor 1 enhances its stability and promotes the progression of triple-negative breast cancer.Cell death discovery · 2022Article
- Commonalities of optic nerve injury and glaucoma-induced neurodegeneration: Insights from transcriptome-wide studies.Experimental eye research · 2021Review
- Checkpoint suppressor 1 suppresses transcriptional activity of ERα and breast cancer cell proliferation via deacetylase SIRT1.Cell death & disease · 2018Article
- KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models.Oncotarget · 2015Article
- Protein kinase C δ increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes.The Journal of biological chemistry · 2013Article
- Article
- Emerging stem cell therapies: treatment, safety, and biology.Stem cells international · 2012Article
- Dysregulation of Kruppel-like factor 4 during brain development leads to hydrocephalus in mice.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Expression profiling and pathway analysis of Krüppel-like factor 4 in mouse embryonic fibroblasts.American journal of cancer research · 2011Article
- Mammalian Krüppel-like factors in health and diseases.Physiological reviews · 2010Review
- The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells.Histology and histopathology · 2009Review
- Expression and Function of Kruppel Like-Factors (KLF) in Carcinogenesis.Current genomics · 2009Article
- Loss of heterozygosity at chromosome 14q is associated with poor prognosis in head and neck squamous cell carcinomas.Journal of cancer research and clinical oncology · 2008Article
- Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium.Molecular cancer research : MCR · 2008Article
- Identification of candidate Klf4 target genes reveals the molecular basis of the diverse regulatory roles of Klf4 in the mouse cornea.Investigative ophthalmology & visual science · 2008Article
- Roles of Krüpel-like factor 4 in normal homeostasis, cancer and stem cells.Acta biochimica et biophysica Sinica · 2008Review
- Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis.Cancer research · 2007Article
- The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology.BioEssays : news and reviews in molecular, cellular and developmental biology · 2007Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Krüppel-like factor 4 (KLF4; also known as gut-enriched Krüppel-like factor or GKLF) is known to exhibit checkpoint function during the G1/S and G2/M transitions of the cell cycle. The mechanism by which KLF4 exerts these effects is not fully established. Here we investigated the expression profile of KLF4 in an inducible system over a time course of 24 h. Using oligonucleotide microarrays, we determined that the fold changes relative to control in expression levels of KLF4 exhibited a time-dependent increase from 3- to 20-fold between 4 and 24 h following KLF4 induction. During this period and among a group of 473 cell cycle regulatory genes examined, 96 were positively correlated and 86 were negatively correlated to KLF4's expression profile. Examples of upregulated cell cycle genes include those encoding tumor suppressors such as MCC and FHIT, and cell cycle inhibitors such as CHES1 and CHEK1. Examples of downregulated genes include those that promote the cell cycle including several cyclins and those required for DNA replication. Unexpectedly, several groups of genes involved in macromolecular synthesis, including protein biosynthesis, transcription, and cholesterol biosynthesis, were also significantly inhibited by KLF4. Thus, KLF4 exerts a global inhibitory effect on macromolecular biosynthesis that is beyond its established role as a cell cycle inhibitor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.