ArticleVirchows Archiv : an international journal of pathology2006
Histopathologic indicators of recurrence in meningiomas: correlation with clinical and genetic parameters.
Article in Virchows Archiv : an international journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Biomarkers for prognosis of meningioma patients: A systematic review and meta-analysis.PloS one · 2024Pooled it
- Prognostic significance of brain invasion in meningiomas: systematic review and meta-analysis.Brain tumor pathology · 2021Pooled it
- The prognostic role of Ki-67/MIB-1 in meningioma: A systematic review with meta-analysis.Medicine · 2020Pooled it
- Risk Factors for Tumor Recurrence in Meningiomas: Multicenter Multivariate Analysis.Indian journal of surgical oncology · 2025Review
- RNA-seq transcriptome analysis of formalin fixed, paraffin-embedded canine meningioma.PloS one · 2017Article
- Proposal for a new risk stratification classification for meningioma based on patient age, WHO tumor grade, size, localization, and karyotype.Neuro-oncology · 2014Article
- A retrospective analysis of survival and prognostic factors after stereotactic radiosurgery for aggressive meningiomas.Radiation oncology (London, England) · 2014Article
- Extensive growth of an anaplastic meningioma.Case reports in neurological medicine · 2013Article
- Tumor grade-related NDRG2 gene expression in primary and recurrent intracranial meningiomas.Journal of neuro-oncology · 2011Article
- Gamma knife radiosurgery of meningiomas involving the foramen magnum.Journal of craniovertebral junction & spine · 2010Article
- WHO grade II and III meningiomas: a study of prognostic factors.Journal of neuro-oncology · 2009Article
- A case of rapid-growing anaplastic meningiomas.BMJ case reports · 2009Article
- [Meningiomas: multiparametric approach for risk stratification and grading].Der Pathologe · 2008Article
- Expression of cell adhesion proteins and proteins related to angiogenesis and fatty acid metabolism in benign, atypical, and anaplastic meningiomas.Journal of neuro-oncology · 2008Article
- Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysis.Virchows Archiv : an international journal of pathology · 2008Article
- New prospects for management and treatment of inoperable and recurrent skull base meningiomas.Journal of neuro-oncology · 2008Review
- Loss of heterozygosity studies in extracranial metastatic meningiomas.Journal of neuro-oncology · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meningiomas in general are circumscribed slow-growing tumors. However, despite gross total resection, tumor relapse and patients' outcome are still an issue. Risk stratification based on histomorphology alone remains problematic. This study explored the independent prognostic value of potential risk factors among 206 patients who underwent meningioma resection and followed-up until death or a median of 44 months. The statistical analysis considered clinical data, histomorphologic parameters, cytogenetic findings, Ki-67 immunoreactivity, and activity of tissue non-specific alkaline phosphatase (ALPL). Recurrence-free survival estimates were computed and prognostic factors were identified using Cox proportional hazards model. Independent predictors of recurrence included (1) anaplasia; (2) mitotic index > or =20/10 high-power fields; (3) subtotal tumor resection; (4) loss of short arm of chromosome 1 (1p-); and (5) Ki-67 labeling index (LI) >12%. Among totally resected WHO grade I meningiomas, neither histopathologic nor clinical parameters were predictive, whereas 1p- was the only independent prognostic factor. ALPL did not reach significance in the multivariate modeling, however, the fast and low-cost histochemical detection of ALPL expression could be proved as a highly sensitive screening method for 1p-. In particular, biologically aggressive meningiomas of histologically benign or "borderline" phenotype could be therefore identified by ALPL detection followed by 1p in situ hybridization.
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