ArticlePsychopharmacology2006
Guanfacine produces differential effects in frontal cortex compared with striatum: assessed by phMRI BOLD contrast.
Article in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 40 citations in OpenAlex.
- Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings.Journal of psychopharmacology (Oxford, England) · 2012Trial
- Guanfacine as a Treatment Option for Persistent Mental Restlessness and Deliberate Self-harm Thoughts in a Patient with Attention-deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Borderline Personality Disorder, and Post-traumatic Stress Disorder: Case Report.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Drug-induced stuttering: A comprehensive literature review.World journal of psychiatry · 2022Review
- Evaluating Guanfacine Hydrochloride in the Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adult Patients: Design, Development and Place in Therapy.Drug design, development and therapy · 2021Review
- Guanfacine Extended Release: A New Pharmacological Treatment Option in Europe.Clinical drug investigation · 2016Review
- Review
- Dissociable effects of noradrenaline, dopamine, and serotonin uptake blockade on stop task performance in rats.Psychopharmacology · 2009Article
- Peculiar response to methylphenidate in adolescent compared to adult rats: a phMRI study.Psychopharmacology · 2009Article
- Pharmacological and therapeutic directions in ADHD: Specificity in the PFC.Behavioral and brain functions : BBF · 2008Article
- Cognitive neuroscience of Attention Deficit Hyperactivity Disorder: current status and working hypotheses.Developmental disabilities research reviews · 2008Review
- Differential effects of the D- and L- isomers of amphetamine on pharmacological MRI BOLD contrast in the rat.Psychopharmacology · 2007Article
- Guanfacine and guanfacine extended release: treatment for ADHD and related disorders.CNS drug reviews · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleGuanfacine (an alpha-(2A) adrenoreceptor agonist) is a drug of benefit in the treatment of attention deficit hyperactivity disorder (ADHD) (Taylor FB, Russo J, J Clin Psychopharmacol 21:223-228, 2001). Assessment of this drug using neuroimaging will provide information about the brain regions involved in its effects.
objectivesThe pharmacological magnetic resonance imaging blood oxygenation level dependent (BOLD) response was determined in rat brain regions following administration of guanfacine.
methodsMale rats were individually placed into a 2.35 T Bruker magnet for 60 min to achieve basal recording of changes in signal intensity. Either saline (n = 9) or guanfacine (0.3 mg/kg, i.p.; n = 9) was then administered and recording was continued for a further 90 min. Data were analysed for BOLD effects using statistical parametric maps. Respiration rate, blood pressure and blood gases were monitored and remained constant throughout scanning.
resultsThe main changes observed were negative BOLD effects in the caudate putamen and nucleus accumbens with positive BOLD effects in frontal association, prelimbic and motor cortex areas.
conclusionsThese data suggest that guanfacine can decrease neuronal activity in the caudate while increasing frontal cortex activity. This ability to change neuronal activity in specific areas of rat brain that are known to be impaired in ADHD (Solanto MV, Behav Brain Res 130:65-71, 2002) may contribute to guanfacine's beneficial effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.