ArticleDiabetologia2006
Increased islet beta cell replication adjacent to intrapancreatic gastrinomas in humans.
Article in Diabetologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Review
- Dysregulation of β-Cell Proliferation in Diabetes: Possibilities of Combination Therapy in the Development of a Comprehensive Treatment.Biomedicines · 2022Review
- Pancreatic β-cell heterogeneity in health and diabetes: classes, sources, and subtypes.American journal of physiology. Endocrinology and metabolism · 2021Review
- Alterations in Beta Cell Identity in Type 1 and Type 2 Diabetes.Current diabetes reports · 2019Review
- Article
- Regenerating β cells of the pancreas - potential developments in diabetes treatment.Expert opinion on biological therapy · 2018Review
- Heterogeneity in the Beta-Cell Population: a Guided Search Into Its Significance in Pancreas and in Implants.Current diabetes reports · 2017Review
- An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration.Developmental biology · 2016Article
- Effect of proton pump inhibitors on glycemic control in patients with diabetes.World journal of diabetes · 2015Article
- Pantoprazole may improve beta cell function and diabetes mellitus.Journal of endocrinological investigation · 2014Article
- β-cell preservation and regeneration for diabetes treatment: where are we now?Diabetes management (London, England) · 2012Article
- Improved diabetes control and pancreatic function in a type 2 diabetic after omeprazole administration.Case reports in endocrinology · 2012Article
- Islet neogenesis: a possible pathway for beta-cell replenishment.The review of diabetic studies : RDS · 2012Review
- Article
- Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass.Experimental diabetes research · 2011Review
- Review
- FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation.Molecular endocrinology (Baltimore, Md.) · 2010Article
- Pancreatic β-Cell Mass as a Pharmacologic Target in Diabetes.McGill journal of medicine : MJM : an international forum for the advancement of medical sciences by students · 2009Article
- Minireview: Meeting the demand for insulin: molecular mechanisms of adaptive postnatal beta-cell mass expansion.Molecular endocrinology (Baltimore, Md.) · 2009Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisType 1 and type 2 diabetes are characterised by a beta cell deficit. Islet hyperplasia has been described in patients with Zollinger-Ellison syndrome secondary to gastrin-producing tumours (gastrinomas), and gastrin therapy has increased beta cell mass in rodents and human islets in vitro. In the present studies we addressed the following questions: (1) In pancreas specimens from gastrinoma cases, is the fractional beta cell area increased? (2) If so, is this restricted to tumour-adjacent islets or also present in tumour-distant islets? (3) Is new beta cell formation (beta cell replication and islet neogenesis) increased and beta cell apoptosis decreased in pancreas specimens from gastrinoma cases?
methodsPancreas was obtained at surgery from four patients with Zollinger-Ellison syndrome caused by pancreatic gastrinomas and 15 control subjects at autopsy.
resultsIslet fractional beta cell area (p<0.001), islet size (p<0.001) and beta cell replication (Ki67 staining) (p<0.05) were increased in islets adjacent to the tumours, but not in tumour-distant pancreas, compared with control subjects. We did not observe any differences in beta cell apoptosis or in the number of insulin-positive cells in ducts either adjacent to or distant from the tumour. CONCLUSIONS/
interpretationOne or more factors released by human gastrinomas increase beta cell replication in islets immediately adjacent to the tumour, but not in tumour-distant islets. While these findings demonstrate that adult human beta cells can be driven into the cell cycle, they caution against the therapeutic usefulness of gastrin, since islets located >1 cm away from the gastrinomas did not exhibit changes in beta cell turnover, despite markedly elevated systemic gastrin levels sufficient to cause severe gastrointestinal symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.