ArticleThe pharmacogenomics journal2007
The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.
Article in The pharmacogenomics journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Clinical, Biochemical and Genetic Variables Associated With Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders Using Second-Generation Antipsychotics: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Polymorphisms of theJournal of clinical medicine · 2025Review
- A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis.International journal of molecular sciences · 2021Article
- Drug-naive patients with schizophrenia have metabolic disorders that are not associated with polymorphisms in the LEP (-2548G/A) and 5-HTR2C (-759C/T) genes.International journal of clinical and experimental pathology · 2018Article
- 759C/T Variants of the Serotonin (5-HT2C) Receptor Gene and Weight Gain in Children and Adolescents in Long-Term Risperidone Treatment.Clinical pharmacology & biopharmaceutics · 2013Article
- From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics.International journal of clinical pharmacy · 2013Review
- Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine.Psychopharmacology · 2013Article
- Pharmacogenetics of antipsychotic-induced weight gain: review and clinical implications.Molecular psychiatry · 2012Review
- Review
- Association of genetic variants of the histamine H1 and muscarinic M3 receptors with BMI and HbA1c values in patients on antipsychotic medication.Psychopharmacology · 2011Article
- From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics.International journal of clinical pharmacy · 2011Review
- Role of 5-HT(2C) receptor gene variants in antipsychotic-induced weight gain.Pharmacogenomics and personalized medicine · 2011Article
- Management of antipsychotic-related weight gain.Expert review of neurotherapeutics · 2010Review
- The promise and reality of pharmacogenetics in psychiatry.The Psychiatric clinics of North America · 2010Review
- The association between antidepressant use and disturbances in glucose homeostasis: evidence from spontaneous reports.European journal of clinical pharmacology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of antipsychotics is associated with an increased risk of obesity. This consideration makes it important to search for determinants that can predict the risk for antipsychotic-induced obesity. In this cross-sectional study, we investigated whether polymorphisms in the HTR2C gene were associated with obesity (body mass index >30 kg/m2) in patients using antipsychotics. We examined polymorphisms in the promoter region of the HTR2C gene ((HTR2C:c.1-142948(GT)n, rs3813928 (-997 G/A), rs3813929 (-759 C/T), rs518147 (-697 G/C)) and an intragenic polymorphism (rs1414334:C>G). The results of the logistic regression were expressed as adjusted odds ratios (OR). In total, we included 127 patients mainly diagnosed with schizophrenia or schizoaffective disorder (89%). The results indicate that a combined genotype carrying the variant HTR2C:c.1-142948(GT)n 13 repeat allele, the common allele rs3813929 C, the variant allele rs518147 C and the variant allele rs1414334 C is significantly related to an increased risk of obesity (OR 3.71 (95% confidence interval: 1.24-11.12)).
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