ReviewGene therapy2006
Progress and prospects: gene transfer into embryonic stem cells.
Review in Gene therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Electrospun Nanofibers for Cancer Therapy.Advances in experimental medicine and biology · 2021Review
- Human embryonic stem cells form functional thyroid follicles.Thyroid : official journal of the American Thyroid Association · 2015Article
- Electrospun nanofibers as versatile interfaces for efficient gene delivery.Journal of biological engineering · 2014Review
- Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Article
- DiR-labeled Embryonic Stem Cells for Targeted Imaging of in vivo Gastric Cancer Cells.Theranostics · 2012Article
- Gene editing of human embryonic stem cells via an engineered baculoviral vector carrying zinc-finger nucleases.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- Efficient, high-throughput transfection of human embryonic stem cells.Stem cell research & therapy · 2010Article
- Genetic manipulation of neural progenitors derived from human embryonic stem cells.Tissue engineering. Part A · 2009Article
- High-efficiency transient transduction of human embryonic stem cell-derived neurons with baculoviral vectors.Molecular therapy : the journal of the American Society of Gene Therapy · 2009Article
- A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells.Stem cells (Dayton, Ohio) · 2009Article
- Nanoparticles for gene transfer to human embryonic stem cell colonies.Nano letters · 2008Article
- Stable gene transfer of CCR5 and CXCR4 siRNAs by sleeping beauty transposon system to confer HIV-1 resistance.AIDS research and therapy · 2008Article
- Nucleofection mediates high-efficiency stable gene knockdown and transgene expression in human embryonic stem cells.Stem cells (Dayton, Ohio) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the isolation of human embryonic stem cells (hESCs) in 1998 came the realization of a long-sought aspiration for an unlimited source of human tissue. The difficulty of differentiating ESCs to pure, clinically exploitable cell populations to treat genetic and degenerative diseases is being solved in part with the help of genetically modified cell lines. With progress in genome editing and somatic cell nuclear transfer, it is theoretically possible to obtain genetically repaired isogenic cells. Moreover, the prospect of being able to select, isolate and expand a single cell to a vast population of cells could achieve a unique level of quality control, until now unattainable in the field of gene therapy. Most of the tools necessary to develop these strategies already exist in the mouse ESC system. We review here the advances accomplished in those fields and present some possible applications to hESC research.
Indexed as
Identifiers
17016468What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.