ArticleProceedings of the National Academy of Sciences of the United States of America2006
Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 143 citations in OpenAlex.
- Emerging technologies for advancing molecular and cellular research in bats.Zoological research · 2026Review
- Molecular analysis of Aldh1a2 conditional inactivation in developing limbs reveals mechanisms of retinoic-acid mediated interdigital apoptosis.Frontiers in cell and developmental biology · 2026Article
- BMP-Dependent Modulation of ROS Generation and Scavenging Controls Interdigital Cell Death.Development, growth & differentiation · 2026Article
- Great expectations: altricial developmental strategies are associated with more flexible evolution of limb skeleton proportions in birds.Proceedings. Biological sciences · 2025Article
- Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development.Nature ecology & evolution · 2025Article
- Single-cell expression profiling of bat wing development.Nature communications · 2025Article
- A Notch signal required for a morphological novelty inScience advances · 2025Article
- Adaptive evolution ofZoological research · 2025Article
- Transcriptome data from the interdigital webs of the Chinese Soft-shell Turtle (Pelodiscus sinensis).Scientific data · 2025Article
- Comparative transcriptomics in serial organs uncovers early and pan-organ developmental changes associated with organ-specific morphological adaptation.Nature communications · 2025Article
- Evolutionary integration of forelimb and hindlimb proportions within the bat wing membrane inhibits ecological adaptation.Nature ecology & evolution · 2025Article
- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Protein signaling and morphological development of the tail fluke in the embryonic beluga whale (Delphinapterus leucas).Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- Palaeoatmosphere facilitates a gliding transition to powered flight in the Eocene bat, Onychonycteris finneyi.Communications biology · 2024Article
- Key separable events in the remodelling of the pharyngeal arches.Journal of anatomy · 2023Article
- Insights into the formation and diversification of a novel chiropteran wing membrane from embryonic development.BMC biology · 2023Article
- Convergent deployment of ancestral functions during the evolution of mammalian flight membranes.Science advances · 2023Article
- Timing of organogenesis underscores the evolution of neonatal life histories and powered flight in bats.Proceedings. Biological sciences · 2023Article
- Air-breathing behavior underlies the cell death in limbs of Rana pirica tadpoles.Zoological letters · 2023Article
- Evolutionary genetics of flipper forelimb and hindlimb loss from limb development-related genes in cetaceans.BMC genomics · 2022Article
5 more citing papers are in PubMed but not listed here.
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4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmentally regulated programmed cell death sculpts the limbs and other embryonic organs in vertebrates. One intriguing example of species-specific differences in apoptotic extent is observed in the tissue between the digits. In chicks and mice, bone morphogenetic proteins (Bmps) trigger apoptosis of the interdigital mesenchyme, leading to freed digits, whereas in ducks, Bmp antagonists inhibit the apoptotic program, resulting in webbed feet. Here, we show that the phyllostomid bat Carollia perspicillata utilizes a distinct mechanism for maintaining interdigit tissue. We find that bat forelimb and hindlimb interdigital tissues express Bmp signaling components but that only bat hindlimbs undergo interdigital apoptosis. Strikingly, the retention of interdigital webbing in the bat forelimb is correlated with a unique pattern of Fgf8 expression in addition to the Bmp inhibitor Gremlin. By using a functional assay, we show that maintenance of interdigit tissue in the bat wing depends on the combined effects of high levels of Fgf signaling and inhibition of Bmp signaling. Our data also indicate that although there is not a conserved mechanism for maintaining interdigit tissue across amniotes, the expression in the bat forelimb interdigits of Gremlin and Fgf8 suggests that these key molecular changes contributed to the evolution of the bat wing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.