ArticleJournal of bacteriology2006
Interrelations between glycine betaine catabolism and methionine biosynthesis in Sinorhizobium meliloti strain 102F34.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 53 citations in OpenAlex.
- Methionine synthesis and glycine betaine demethylation are intricately intertwined in cosmopolitan marine bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- DmdA-independent lag phase shortening in Phaeobacter inhibens bacteria under stress conditions.The FEBS journal · 2025Article
- Dual roles of glycine betaine, dimethylglycine, and sarcosine as osmoprotectants and nutrient sources forApplied and environmental microbiology · 2025Article
- Glycine betaine metabolism is enabled inApplied and environmental microbiology · 2024Article
- Choline degradation inJournal of bacteriology · 2024Article
- Glycine betaine uptake and metabolism in marine microbial communities.Environmental microbiology · 2022Article
- Role ofApplied and environmental microbiology · 2020Article
- Exo-Metabolites ofMetabolites · 2019Article
- Glycine Betaine Monooxygenase, an Unusual Rieske-Type Oxygenase System, Catalyzes the OxidativeApplied and environmental microbiology · 2018Article
- Comparative genomics and mutagenesis analyses of choline metabolism in the marine Roseobacter clade.Environmental microbiology · 2015Article
- Nitrogen-Fixing Nodules Are an Important Source of Reduced Sulfur, Which Triggers Global Changes in Sulfur Metabolism in Lotus japonicus.The Plant cell · 2015Article
- A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Homeostasis and catabolism of choline and glycine betaine: lessons from Pseudomonas aeruginosa.Applied and environmental microbiology · 2013Review
- Phaeobacter gallaeciensis genomes from globally opposite locations reveal high similarity of adaptation to surface life.The ISME journal · 2012Article
- Small-molecule inhibition of choline catabolism in Pseudomonas aeruginosa and other aerobic choline-catabolizing bacteria.Applied and environmental microbiology · 2011Article
- Comparative genome analysis and genome-guided physiological analysis of Roseobacter litoralis.BMC genomics · 2011Article
- Studies of dimethylglycine oxidase isoenzymes in Arthrobacter globiformis cells.Current microbiology · 2011Article
- One carbon metabolism in SAR11 pelagic marine bacteria.PloS one · 2011Article
- Sinorhizobium meliloti requires a cobalamin-dependent ribonucleotide reductase for symbiosis with its plant host.Molecular plant-microbe interactions : MPMI · 2010Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Methionine is produced by methylation of homocysteine. Sinorhizobium meliloti 102F34 possesses only one methionine synthase, which catalyzes the transfer of a methyl group from methyl tetrahydrofolate to homocysteine. This vitamin B(12)-dependent enzyme is encoded by the metH gene. Glycine betaine can also serve as an alternative methyl donor for homocysteine. This reaction is catalyzed by betaine-homocysteine methyl transferase (BHMT), an enzyme that has been characterized in humans and rats. An S. meliloti gene whose product is related to the human BHMT enzyme has been identified and named bmt. This enzyme is closely related to mammalian BHMTs but has no homology with previously described bacterial betaine methyl transferases. Glycine betaine inhibits the growth of an S. meliloti bmt mutant in low- and high-osmotic strength media, an effect that correlates with a decrease in the catabolism of glycine betaine. This inhibition was not observed with other betaines, like homobetaine, dimethylsulfoniopropionate, and trigonelline. The addition of methionine to the growth medium allowed a bmt mutant to recover growth despite the presence of glycine betaine. Methionine also stimulated glycine betaine catabolism in a bmt strain, suggesting the existence of another catabolic pathway. Inactivation of metH or bmt did not affect the nodulation efficiency of the mutants in the 102F34 strain background. Nevertheless, a metH strain was severely defective in competing with the wild-type strain in a coinoculation experiment.
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