ArticleCancer cell international2006
Expression of platelet derived growth factor family members and the potential role of imatinib mesylate for cervical cancer.
Article in Cancer cell international, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
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- Prevalence of Angiogenesis, Proliferation, and Apoptosis Markers of Cervical Cancer and Their Correlation with Clinicopathological Parameters.Journal of oncology · 2020Article
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- Combination of Preoperative D-Dimer and Platelet Distribution width Predicts Postoperative Deep Venous Thrombosis in Patients with Cervical CarcinomaAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Enhanced Delivery of Imatinib into Vaginal Mucosa via a New Positively Charged Nanocrystal-Loaded in Situ Hydrogel Formulation for Treatment of Cervical Cancer.Pharmaceutics · 2019Article
- Mutation analysis of EGFR and its correlation with the HPV in Indian cervical cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combination of active targeting and molecular targeting.International journal of nanomedicine · 2014Article
- Early transcriptional pattern of angiogenesis induced by EGCG treatment in cervical tumour cells.Journal of cellular and molecular medicine · 2012Article
- Identification of signature genes for detecting hedgehog pathway activation in esophageal cancer.Pathology oncology research : POR · 2011Article
- Review
- Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma.BMC cancer · 2009Article
- Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting.PLoS medicine · 2008Article
- Identification of signature genes for detecting hedgehog signaling activation in gastric cancer.Molecular medicine reportsArticle
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite significant achievements in the treatment of cervical cancer, it is still a deadly disease; hence newer therapeutical modalities are needed. Preliminary investigations suggest that platelet-derived growth factor (PDGF) might have a role in the development of cervical cancer, therefore it is important to determine whether this growth factor pathway is functional and its targeting with imatinib mesylate leads to growth inhibition of cervical cancer cells.
resultsPDGF receptors (PDGFR) and their ligands are frequently expressed in cervical cancer and the majority exhibited a combination of family members co-expression. A number of intronic and exonic variations but no known mutations in the coding sequence of the PDGFRalpha gene were found in cancer cell lines and primary tumors. Growth assays demonstrated that PDGFBB induces growth stimulation that can be blocked by imatinib and that this tyrosine kinase inhibitor on its own inhibits cell growth. These effects were associated with the phosphorylation status of the receptor.
conclusionThe PDGFR system may have a role in the pathogenesis of cervical cancer as their members are frequently expressed in this tumor and cervical cancer lines are growth inhibited by the PDGFR antagonist imatinib.
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