Trial reportArthritis research & therapy2006
Is disturbed clearance of apoptotic keratinocytes responsible for UVB-induced inflammatory skin lesions in systemic lupus erythematosus?
Trial report in Arthritis research & therapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- An Overview of the Pathogenesis of Cutaneous Lupus Erythematosus.Journal of clinical medicine · 2025Review
- DNA Containing Cyclobutane Pyrimidine Dimers Is Released from UVB-Irradiated Keratinocytes in a Caspase-Dependent Manner.The Journal of investigative dermatology · 2022Article
- Recent advances in cutaneous lupus.Journal of autoimmunity · 2022Review
- Immune Cell-Stromal Circuitry in Lupus Photosensitivity.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis.Frontiers in immunology · 2020Review
- Mechanistic insights into environmental and genetic risk factors for systemic lupus erythematosus.American journal of translational research · 2019Review
- A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity.Science translational medicine · 2018Article
- Crosstalk Between Apoptosis and Autophagy: Environmental Genotoxins, Infection, and Innate Immunity.Journal of cell death · 2017Review
- Cutaneous lupus erythematosus: updates on pathogenesis and associations with systemic lupus.Current opinion in rheumatology · 2016Review
- Lupus erythematosus revisited.Seminars in immunopathology · 2016Review
- Pathophysiology of cutaneous lupus erythematosus.Arthritis research & therapy · 2015Review
- Recent developments in the role of high-mobility group box 1 in systemic lupus erythematosus.Molecular medicine (Cambridge, Mass.) · 2014Review
- Monocytes from Irf5-/- mice have an intrinsic defect in their response to pristane-induced lupus.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Toll-like receptor driven B cell activation in the induction of systemic autoimmunity.Seminars in immunology · 2011Review
- Disturbances of apoptotic cell clearance in systemic lupus erythematosus.Arthritis research & therapy · 2011Review
- Current and emerging strategies for the treatment and management of systemic lupus erythematosus based on molecular signatures of acute and chronic inflammation.Journal of inflammation research · 2010Article
- Sunlight triggers cutaneous lupus through a CSF-1-dependent mechanism in MRL-Fas(lpr) mice.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Shining light on lupus and UV.Arthritis research & therapy · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Apoptotic cells are thought to play an essential role in the pathogenesis of systemic lupus erythematosus (SLE). We hypothesise that delayed or altered clearance of apoptotic cells after UV irradiation will lead to inflammation in the skin of SLE patients. Fifteen SLE patients and 13 controls were irradiated with two minimal erythemal doses (MEDs) of ultraviolet B light (UVB). Subsequently, skin biopsies were analysed (immuno)histologically, over 10 days, for numbers of apoptotic cells, T cells, macrophages, and deposition of immunoglobulin and complement. Additionally, to compare results with cutaneous lesions of SLE patients, 20 biopsies of lupus erythematosus (LE) skin lesions were analysed morphologically for apoptotic cells and infiltrate. Clearance rate of apoptotic cells after irradiation did not differ between patients and controls. Influx of macrophages in dermal and epidermal layers was significantly increased in patients compared with controls. Five out of 15 patients developed a dermal infiltrate that was associated with increased epidermal influx of T cells and macrophages but not with numbers of apoptotic cells or epidermal deposition of immunoglobulins. Macrophages were ingesting multiple apoptotic bodies. Inflammatory lesions in these patients were localised near accumulations of apoptotic keratinocytes similar as was seen in the majority of LE skin lesions. In vivo clearance rate of apoptotic cells is comparable between SLE patients and controls. However, the presence of inflammatory lesions in the vicinity of apoptotic cells, as observed both in UVB-induced and in LE skin lesions in SLE patients, suggests that these lesions result from an inflammatory clearance of apoptotic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.