ReviewInternational orthopaedics2006
Giant cell tumour of bone: morphological, biological and histogenetical aspects.
Review in International orthopaedics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07315828 (A Prospective Study on the Accuracy of Indocyanine Green Fluorescence Imaging for the Visualization of Residual Lesions in the Tumor Cavity During Surgery for Giant Cell Tumor of Bone), which is not on this map. Cited by 106 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Study on the Accuracy of Indocyanine Green Fluorescence Imaging for the Visualization of Residual Lesions in the Tumor Cavity During Surgery for Giant Cell Tumor of Bone
Who cites it
106 citing papers in PubMed.
- Unnoticed Giant Cell Tumor of the Left Distal Tibia in a 52-Year-Old Male: A Rare Case Report.Journal of orthopaedic case reports · 2026Article
- Sinonasal giant cell tumour. Report of four cases and review of the literature.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2026Review
- A Novel Approach to Proximal Humerus Giant Cell Tumor: Cement Spacer and Screw Interdigitation for Optimal Stability.Journal of orthopaedic case reports · 2026Article
- Giant Cell Tumor of Bone: Biology, Pathophysiology, and Histopathology in the Era of H3F3A.Biomedicines · 2026Review
- Reconstruction of Recurrent First Metatarsal Giant Cell Tumor with Vascularized Metatarsal Transfer: Long-Term Functional Outcomes.Journal of orthopaedic case reports · 2026Article
- Brown tumor mimicking giant cell tumor in primary hyperparathyroidism: a case report.Journal of medical case reports · 2025Article
- Malignant Giant Cell Tumor of Bone: A Study of Clinical, Pathological, and Prognostic Profile from One Single Center.Bioengineering (Basel, Switzerland) · 2025Article
- A Rare Case Report of Giant Cell Tumor in Metacarpal Bone.Journal of orthopaedic case reports · 2025Article
- Transoral Resection of a Giant Cell Tumor in the Odontoid With Cementoplasty: A Technical Case Report.Neurosurgery practice · 2025Article
- The Giant Cell Tumor of 1st Metatarsal in a Young Adult: A Rare Versatile Management with Fibula Cortical Graft.Journal of orthopaedic case reports · 2025Article
- Investigating the Challenges in Diagnosis and Management of Giant Cell Tumors in the Distal Phalanx: A Case Report.Cureus · 2025Article
- H3.3-G34W in giant cell tumor of bone functionally aligns with the exon choice repressor hnRNPA1L2.Cancer gene therapy · 2024Article
- Distal Ulna Giant Cell Tumor treated by Resection without Reconstruction: What were the functional outcomes and review of literature.Journal of orthopaedics · 2024Review
- Giant Cell Tumor of the Temporal Bone with Direct Invasion into the Middle Ear and Skull Base: A Case Report.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Giant Cell Tumor of Bone, Rare Inferior Orbit Location.Plastic and reconstructive surgery. Global open · 2024Article
- Human Chorionic Gonadotropin Regulates the Smad Signaling Pathway by Antagonizing TGF-β in Giant Cell Tumor of Bone.Recent patents on anti-cancer drug discovery · 2024Article
- A Rare Case of Giant Cell Tumour of the Medial Epicondyle of the Humerus Managed With Curettage and Bone Grafting.Cureus · 2023Article
- Giant Cell Tumor of Thumb Proximal Phalanx-A Case Report.Journal of orthopaedic case reports · 2023Article
- Aggressive giant cell lesion of mandible-confusing to common: true neoplasm versus reactive lesion.BMJ case reports · 2023Article
- Management of a rare giant cell tumor of the distal fibula: A case report.World journal of clinical cases · 2023Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The giant cell tumour of bone (GCT) is a locally aggressive intraosseous neoplasm of obscure biological behaviour. Although well defined in clinical, radiological and histological terms, detailed information on its biological development is still relatively incomplete. The tumoral tissue consists of three cell types--the neoplastic giant cell tumour stromal cells (GCTSC), representing the proliferative fraction, secondarily recruited mononuclear histiocytic cells (MNHC) and multinuclear giant cells (MNGC). These cellular components interact together with factors that have a role in regulating osteoclast function in normal bone tissue (e.g. RANK, RANKL, OPG, M-CSF). Recent publications suggest that the neoplastic stromal cells express differentiation features of mesenchymal stem cells. Further research of the pathogenesis of GCT as well as the complex interactions of its cellular populations may provide the knowledge necessary for developing approaches for a biological-based therapy of this neoplasm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.