Trial reportPsychopharmacology2006
Impaired recognition of fear facial expressions in 5-HTTLPR S-polymorphism carriers following tryptophan depletion.
Trial report in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- The genetic underpinnings of callous-unemotional traits: A systematic research review.Neuroscience and biobehavioral reviews · 2019Pooled it
- Empathic accuracy and oxytocin after tryptophan depletion in adults at risk for depression.Psychopharmacology · 2016Trial
- Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure.Psychopharmacology · 2009Trial
- The role of 5-HTTLPR in choosing the lesser of two evils, the better of two goods: examining the impact of 5-HTTLPR genotype and tryptophan depletion in object choice.Psychopharmacology · 2008Trial
- Threat-Avoidance Tendencies Moderate the Link Between Serotonin Transporter Genetic Variation and Reactive Aggression.Frontiers in behavioral neuroscience · 2020Article
- Differences in how macaques monitor others: Does serotonin play a central role?Wiley interdisciplinary reviews. Cognitive science · 2019Review
- Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.Psychopharmacology · 2018Article
- The Neurodevelopmental Basis of Early Childhood Disruptive Behavior: Irritable and Callous Phenotypes as Exemplars.The American journal of psychiatry · 2018Review
- 5-HTTLPR modulates the recognition accuracy and exploration of emotional facial expressions.Frontiers in behavioral neuroscience · 2014Article
- The neurobiology of psychopathic traits in youths.Nature reviews. Neuroscience · 2013Review
- Acute responsivity of the serotonergic system to S-citalopram and positive emotionality-the moderating role of the 5-HTTLPR.Frontiers in human neuroscience · 2013Article
- The effect of raising and lowering tryptophan levels on human mood and social behaviour.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Maternal depressive history, teen 5HTTLPR genotype, and the processing of emotional faces: Exploring mechanisms of risk.Behaviour research and therapy · 2011Article
- Affective cognition and its disruption in mood disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Review
- Effects of acute tryptophan depletion on neural processing of facial expressions of emotion in humans.Psychopharmacology · 2010Article
- Development and validation of the high-quality 'rapid method for swab' to genotype the HTTLPR serotonin transporter (SLC6A4) promoter polymorphism.Psychiatric genetics · 2009Article
- CNTRICS final task selection: social cognitive and affective neuroscience-based measures.Schizophrenia bulletin · 2009Review
- Acute tryptophan depletion dose dependently impairs object memory in serotonin transporter knockout rats.Psychopharmacology · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleGenotype at the 5' promoter region (5-HTTLPR) of the serotonin transporter has been implicated in moderating the effects of acute tryptophan depletion on neurocognitive functioning. Acute tryptophan depletion has been associated with the processing of fear-relevant cues, such as emotional expressions, but the effect of genotype at the 5-HTTLPR has not been assessed.
objectiveThe present study investigated the effects of acute tryptophan depletion on the recognition of standardized facial expressions of emotions in healthy volunteers classified as ll homozygotes or s carriers. MATERIALS AND
methodsA double-blind between-groups design was used with volunteers randomly selected to ingest capsules containing an amino acid mixture specifically lacking tryptophan, or placebo capsules containing lactose. 5 h after capsule ingestion, subjects were required to identify anger, disgust, fear, happiness, sadness, and surprise expressions that progressed from neutral to each full emotional expression in 5% steps.
resultsTryptophan depletion significantly impaired the recognition of fearful facial expressions in s carriers but not ll homozygotes. This impairment was specific to fear expressions. No significant differences in the recognition of other expressions were found. Free tryptophan levels were correlated with fear recognition in s carriers but not ll homozygotes.
conclusionsThe effects of acute tryptophan depletion on the processing of emotional expressions varies as a function of genotype at the 5-HTTLPR. Depletion impairs the recognition of fear in s carriers but not ll homozygotes. This finding reinforces the importance of considering genotype when assessing the behavioral effects of pharmacologic modulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.