ArticleExperimental brain research2007
Time of transplantation and cell preparation determine neural stem cell survival in a mouse model of Huntington's disease.
Article in Experimental brain research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 70 citations in OpenAlex.
- Engineering Mesenchymal Stem Cell Spheroids and Brain Organoids: Advanced 3D Culture Platforms for Neurodegenerative Disease Cell Therapy.Stem cell reviews and reports · 2026Review
- Pathogenesis and potential therapeutic application of stem cells transplantation in Huntington's disease.Regenerative therapy · 2022Review
- Cell-Based Delivery Approaches for DNA-Binding Domains to the Central Nervous System.Current neuropharmacology · 2021Review
- Implantation of the clinical-grade human neural stem cell line, CTX0E03, rescues the behavioral and pathological deficits in the quinolinic acid-lesioned rodent model of Huntington's disease.Stem cells (Dayton, Ohio) · 2020Article
- Successes and Hurdles in Stem Cells Application and Production for Brain Transplantation.Frontiers in neuroscience · 2019Review
- The Effect of Tissue Preparation and Donor Age on Striatal Graft Morphology in the Mouse.Cell transplantation · 2018Article
- Current progress in the derivation and therapeutic application of neural stem cells.Cell death & disease · 2017Review
- Neural Crest Cell Implantation Restores Enteric Nervous System Function and Alters the Gastrointestinal Transcriptome in Human Tissue-Engineered Small Intestine.Stem cell reports · 2017Article
- Induced Pluripotent Stem Cell-Derived Neural Stem Cell Transplantations Reduced Behavioral Deficits and Ameliorated Neuropathological Changes in YAC128 Mouse Model of Huntington's Disease.Frontiers in neuroscience · 2017Article
- Neural and mesenchymal stem cells in animal models of Huntington's disease: past experiences and future challenges.Stem cell research & therapy · 2015Review
- Developing stem cell therapies for juvenile and adult-onset Huntington's disease.Regenerative medicine · 2015Review
- Intrastriatal transplantation of adenovirus-generated induced pluripotent stem cells for treating neuropathological and functional deficits in a rodent model of Huntington's disease.Stem cells translational medicine · 2014Article
- Cell Therapy Strategies vs. Paracrine Effect in Huntington's Disease.Journal of movement disorders · 2014Review
- Article
- Brain tissue interaction with three-dimensional, honeycomb polycaprolactone-based scaffolds designed for cranial reconstruction following traumatic brain injury.Tissue engineering. Part A · 2013Article
- Current challenges for the advancement of neural stem cell biology and transplantation research.Stem cell reviews and reports · 2012Review
- Stress-resistant neural stem cells positively influence regional energy metabolism after spinal cord injury in mice.Journal of molecular neuroscience : MN · 2012Article
- Quantitative analysis of neural stem cell migration and tracer clearance in the rat brain by MRI.Molecular imaging and biology · 2011Article
- Differential fate and functional outcome of lithium chloride primed adult neural progenitor cell transplants in a rat model of Huntington disease.Stem cell research & therapy · 2010Article
- Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell replacement therapies for neurodegenerative diseases, using multipotent neural stem cells (NSCs), require above all, a good survival of the graft. In this study, we unilaterally injected quinolinic acid (QA) into the striatum of adult mice and transplanted syngeneic NSCs of enhanced green fluorescent protein-transgenic mice into the lesioned striatum. The injection of QA leads to an excitotoxic lesion with selective cell death of the medium sized spiny neurons, the same cells that are affected in Huntington's disease. In order to investigate the best timing of transplantation for the survival of donor cells, we transplanted the stem cells at 2, 7 and 14 days after injury. In addition, the influence of graft preparation prior to transplantation, i.e., intact neurospheres versus dissociated cell suspension on graft survival was investigated. By far the best survival was found with the combination of early transplantation (i.e., 2 days after QA-lesion) with the use of neurospheres instead of dissociated cell suspension. This might be due to the different states of host's astrocytic and microglia activation which we found to be moderate at 2, but pronounced at 7 and 14 days after QA-lesion. We also investigated brain derived neurotrophic factor (BDNF)-expression in the striatum after QA-lesion and found no significant change in BDNF protein-level. We conclude that already the method of graft preparation of NSCs for transplantation, as well as the timing of the transplantation procedure strongly affects the survival of the donor cells when grafted into the QA-lesioned striatum of adult mice.
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