ArticleBioprocess and biosystems engineering2006
Metabolic design of macroscopic bioreaction models: application to Chinese hamster ovary cells.
Article in Bioprocess and biosystems engineering, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Multi-Scale Hybrid Modeling to Predict Cell Culture Process With Metabolic Phase Transitions.Biotechnology and bioengineering · 2026Article
- Multiscale modeling guided potency assessment of mRNA-lipid nanoparticles.Molecular therapy. Nucleic acids · 2026Article
- Novel Data-Driven Mechanistic Modeling of Untargeted Metabolome Data Reveals Feed Component Effects in CHO Cell Bioprocess Using Column Generation-Based EFMs.Biotechnology journal · 2025Article
- Article
- Error propagation in constraint-based modeling of Chinese hamster ovary cells.Biotechnology journal · 2021Article
- Cooperative metabolic resource allocation in spatially-structured systems.Journal of mathematical biology · 2021Article
- Dynamic metabolic resource allocation based on the maximum entropy principle.Journal of mathematical biology · 2020Article
- Dynamic Modeling of CHO Cell Metabolism Using the Hybrid Cybernetic Approach With a Novel Elementary Mode Analysis Strategy.Frontiers in bioengineering and biotechnology · 2020Article
- Dynamic metabolic modeling of heterotrophic and mixotrophic microalgal growth on fermentative wastes.PLoS computational biology · 2017Article
- Segmented linear modeling of CHO fed-batch culture and its application to large scale production.Biotechnology and bioengineering · 2017Article
- On dynamically generating relevant elementary flux modes in a metabolic network using optimization.Journal of mathematical biology · 2015Article
- Macroscopic modeling of mammalian cell growth and metabolism.Applied microbiology and biotechnology · 2015Review
- A Single Dynamic Metabolic Model Can Describe mAb Producing CHO Cell Batch and Fed-Batch Cultures on Different Culture Media.PloS one · 2015Article
- Mammalian cell culture process for monoclonal antibody production: nonlinear modelling and parameter estimation.BioMed research international · 2015Article
- Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation.BMC systems biology · 2014Article
- DRUM: a new framework for metabolic modeling under non-balanced growth. Application to the carbon metabolism of unicellular microalgae.PloS one · 2014Article
- Phenotypic characterization of Corynebacterium glutamicum using elementary modes towards synthesis of amino acids.Systems and synthetic biology · 2010Article
- Which metabolic pathways generate and characterize the flux space? A comparison among elementary modes, extreme pathways and minimal generators.Journal of biomedicine & biotechnology · 2010Review
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The aim of this paper is to present a systematic methodology to design macroscopic bioreaction models for cell cultures based upon metabolic networks. The cell culture is seen as a succession of phases. During each phase, a metabolic network represents the set of reactions occurring in the cell. Then, through the use of the elementary flux modes, these metabolic networks are used to derive macroscopic bioreactions linking the extracellular substrates and products. On this basis, as many separate models are obtained as there are phases. Then, a complete model is obtained by smoothly switching from model to model. This is illustrated with batch cultures of Chinese hamster ovary cells.
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