ArticleCell biochemistry and biophysics2006
Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear.
Article in Cell biochemistry and biophysics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
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- Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion.Cardiovascular research · 2014Article
- Shear stress triggers insertion of voltage-gated potassium channels from intracellular compartments in atrial myocytes.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Human-induced pluripotent stem cell-derived cardiomyocytes for studies of cardiac ion transporters.American journal of physiology. Cell physiology · 2013Article
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- Fluid shear attenuates endothelial pseudopodia formation into the capillary lumen.Microcirculation (New York, N.Y. : 1994) · 2008Article
- The sodium-calcium exchanger is a mechanosensitive transporter.The Journal of physiology · 2008Article
- Stimulus interval, rate and direction differentially regulate phosphorylation for mechanotransduction in neonatal cardiac myocytes.FEBS letters · 2007Article
- Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells.Channels (Austin, Tex.)Article
- Cell cultures as models of cardiac mechanoelectric feedback.Progress in biophysics and molecular biologyReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ventricular myocytes are continuously exposed to fluid shear in vivo by relative movement of laminar sheets and adjacent cells. Preliminary observations have shown that neonatal myocytes respond to fluid shear by increasing their beating rate, which could have an arrhythmogenic effect under elevated shear conditions. The objective of this study is to investigate the characteristics of the fluid shear response in cultured myocytes and to study selected potential mechanisms. Cultured neonatal rat ventricular myocytes that were spontaneously beating were subjected to low shear rates (5-50/s) in a fluid flow chamber using standard culture medium. The beating rate was measured from digital microscopic recordings. The myocytes reacted to low shear rates by a graded and reversible increase in their spontaneous beating rate of up to 500%. The response to shear was substantially attenuated in the presence of the beta-adrenergic agonist isoproterenol (by 86+/-8%), as well as after incubation with integrin-blocking RGD peptides (by 92+/-8%). The results suggest that the beta-adrenergic signaling pathway and integrin activation, which are known to interact, may play an important role in the response mechanism.
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