ArticleJournal of bacteriology2006
The ColRS two-component system regulates membrane functions and protects Pseudomonas putida against phenol.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- The two-component system ColRS discriminates metal signals to regulate virulence and resistance in Pseudomonas aeruginosa.PLoS pathogens · 2026Article
- Deciphering the genetic background of an industrial 2-ketogluconic acid-producing strain Pseudomonas plecoglossicida JUIM01 using whole-genome sequencing.Biotechnology for biofuels and bioproducts · 2026Article
- Cellular and molecular outcomes of Pseudomonas putida KT2440 exposure to aluminium.Folia microbiologica · 2025Article
- Transcriptome analysis and cytochrome P450 monooxygenase reveal the molecular mechanism of Bisphenol A degradation by Pseudomonas putida strain YC-AE1.BMC microbiology · 2022Article
- Article
- The TonBJournal of bacteriology · 2019Article
- TheFrontiers in microbiology · 2018Article
- Colonization efficiency of Pseudomonas putida is influenced by Fis-controlled transcription of nuoA-N operon.PloS one · 2018Article
- The promoter region of lapA and its transcriptional regulation by Fis in Pseudomonas putida.PloS one · 2017Article
- Expression of colSR Genes Increased in the rpf Mutants of Xanthomonas oryzae pv. oryzae KACC10859.The plant pathology journal · 2014Article
- The ColRS signal transduction system responds to the excess of external zinc, iron, manganese, and cadmium.BMC microbiology · 2014Article
- A moderate toxin, GraT, modulates growth rate and stress tolerance of Pseudomonas putida.Journal of bacteriology · 2014Article
- Polymyxin resistance of Pseudomonas aeruginosa phoQ mutants is dependent on additional two-component regulatory systems.Antimicrobial agents and chemotherapy · 2013Article
- The ColRS system of Xanthomonas oryzae pv. oryzae is required for virulence and growth in iron-limiting conditions.Molecular plant pathology · 2012Article
- The ColRS system is essential for the hunger response of glucose-growing Pseudomonas putida.BMC microbiology · 2011Article
- The ColR/ColS two-component system plays multiple roles in the pathogenicity of the citrus canker pathogen Xanthomonas citri subsp. citri.Journal of bacteriology · 2011Article
- Characterization of outer membrane proteins of Escherichia coli in response to phenol stress.Current microbiology · 2011Article
- The impact of ColRS two-component system and TtgABC efflux pump on phenol tolerance of Pseudomonas putida becomes evident only in growing bacteria.BMC microbiology · 2010Article
- Identification of ColR binding consensus and prediction of regulon of ColRS two-component system.BMC molecular biology · 2009Article
- The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli.Applied and environmental microbiology · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As reported, the two-component system ColRS is involved in two completely different processes. It facilitates the root colonization ability of Pseudomonas fluorescens and is necessary for the Tn4652 transposition-dependent accumulation of phenol-utilizing mutants in Pseudomonas putida. To determine the role of the ColRS system in P. putida, we searched for target genes of response regulator ColR by use of a promoter library. Promoter screening was performed on phenol plates to mimic the conditions under which the effect of ColR on transposition was detected. The library screen revealed the porin-encoding gene oprQ and the alginate biosynthesis gene algD occurring under negative control of ColR. Binding of ColR to the promoter regions of oprQ and algD in vitro confirmed its direct involvement in regulation of these genes. Additionally, the porin-encoding gene ompA(PP0773) and the type I pilus gene csuB were also identified in the promoter screen. However, it turned out that ompA(PP0773) and csuB were actually affected by phenol and that the influence of ColR on these promoters was indirect. Namely, our results show that ColR is involved in phenol tolerance of P. putida. Phenol MIC measurement demonstrated that a colR mutant strain did not tolerate elevated phenol concentrations. Our data suggest that increased phenol susceptibility is also the reason for inhibition of transposition of Tn4652 in phenol-starving colR mutant bacteria. Thus, the current study revealed the role of the ColRS two-component system in regulation of membrane functionality, particularly in phenol tolerance of P. putida.
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