ArticleJournal of bacteriology2006
Comparative genetics of the rdar morphotype in Salmonella.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Osmotic Stress Adaptation of Poultry-AssociatedFoods (Basel, Switzerland) · 2026Article
- Comparative Biofilmomics of Antimicrobial-ResistantAnimals : an open access journal from MDPI · 2026Review
- Genomic characterization of a virulent multidrug-resistant Salmonella enterica serovar Enteritidis strain isolated from meat rabbits (Oryctolagus cuniculus) in China.BMC microbiology · 2026Article
- A high-resolution genomic and phenotypic analysis of resistance evolution of anJournal of medical microbiology · 2025Article
- Invasive Non-TyphoidalInfection and immunity · 2023Article
- Emergence of novel non-aggregative variants under negative frequency-dependent selection inmicroLife · 2023Article
- Peanut Butter Food Safety Concerns-Prevalence, Mitigation and Control ofFoods (Basel, Switzerland) · 2022Review
- Purification of the Bacterial Amyloid "Curli" fromBio-protocol · 2022Article
- The quorum-sensing systems of Vibrio campbellii DS40M4 and BB120 are genetically and functionally distinct.Environmental microbiology · 2021Article
- A SNP in the Cache 1 Signaling Domain of Diguanylate Cyclase STM1987 Leads to IncreasedInfection and immunity · 2021Article
- Taxonomic and Functional Shifts in the Sprout Spent Irrigation Water Microbiome in Response toApplied and environmental microbiology · 2021Article
- In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection.PLoS pathogens · 2020Article
- Metabolic Activation of CsgD in the Regulation ofMicroorganisms · 2020Article
- Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy.Nature communications · 2020Article
- Monitoring Biofilm Formation and Microbial Interactions that May Occur During aMicroorganisms · 2019Article
- Parallel evolution leading to impaired biofilm formation in invasive Salmonella strains.PLoS genetics · 2019Article
- Causes and Consequences of a Variant Strain ofFrontiers in microbiology · 2018Article
- Thermal Resistance and Gene Expression of both Desiccation-Adapted and Rehydrated Salmonella enterica Serovar Typhimurium Cells in Aged Broiler Litter.Applied and environmental microbiology · 2017Article
- Examining the Link between Biofilm Formation and the Ability of PathogenicFrontiers in veterinary science · 2017Review
- Evidence of Naturalized Stress-Tolerant Strains of Escherichia coli in Municipal Wastewater Treatment Plants.Applied and environmental microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Salmonella rdar morphotype is a distinct, rough and dry colony morphology formed by the extracellular interaction of thin aggregative fimbriae (Tafi or curli), cellulose, and other polysaccharides. Cells in rdar colonies are more resistant to desiccation and exogenous stresses, which is hypothesized to aid in the passage of pathogenic Salmonella spp. between hosts. Here we analyzed the genetic and phenotypic conservation of the rdar morphotype throughout the entire Salmonella genus. The rdar morphotype was conserved in 90% of 80 isolates representing all 7 Salmonella groups; however, the frequency was only 31% in a reference set of 16 strains (Salmonella reference collection C [SARC]). Comparative gene expression analysis was used to separate cis- and trans-acting effects on promoter activity for the 16 SARC strains, focusing on the 780-bp intergenic region containing divergent promoters for the master regulator of the rdar morphotype (agfD) and the Tafi structural genes (agfB). Surprisingly, promoter functionality was conserved in most isolates, and loss of the phenotype was due primarily to defects in trans-acting regulatory factors. We hypothesize that trans differences have been caused by domestication, whereas cis differences, detected for Salmonella enterica subsp. arizonae isolates, may reflect an evolutionary change in lifestyle. Our results demonstrate that the rdar morphotype is conserved throughout the salmonellae, but they also emphasize that regulation is an important source of variability among isolates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.