ArticleJournal of neurology, neurosurgery, and psychiatry2007
Movement disorders in patients taking anticonvulsants.
Article in Journal of neurology, neurosurgery, and psychiatry, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 108 citations in OpenAlex.
- Movement disorders associated with antiseizure medications: A systematic review.Epilepsy & behavior : E&B · 2022Pooled it
- Movement Disorders Secondary to Novel Antiseizure Medications in Pediatric Populations: A Systematic Review and Meta-analysis of Risk.Journal of child neurology · 2022Pooled it
- Risk of Valproic Acid-Related Tremor: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Management of fragile X-associated tremor ataxia syndrome: a review for clinicians.Frontiers in neurology · 2026Review
- Tips and tricks in tremor treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Gabapentin-Associated Movement Disorders: A Literature Review.Medicines (Basel, Switzerland) · 2023Review
- Tremor and Movement Slowness Are Two Unrelated Adverse Effects Induced by Valproate Intake.Movement disorders clinical practice · 2022Article
- Differentiating tardive dyskinesia: a video-based review of antipsychotic-induced movement disorders in clinical practice.CNS spectrums · 2022Review
- Investigation of the risk of valproic acid-induced tremor: clinical, neuroimaging, and genetic factors.Psychopharmacology · 2022Article
- Clinical and Kinematic Features of Valproate-Induced Tremor and Differences with Essential Tremor.Cerebellum (London, England) · 2021Article
- Paroxysmal Genetic Movement Disorders and Epilepsy.Frontiers in neurology · 2021Review
- Clinical Spectrum of Drug-Induced Movement Disorders: A Study of 97 Patients.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Clinical Spectrum of Drug-Induced Movement Disorders: A Study of 97 Patients.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020Article
- Prevalence of Extrapyramidal Symptoms in In-Patients With Severe Mental Illnesses: Focus on Parkinsonism.Frontiers in neurology · 2020Article
- A case of dyskinesia after levetiracetam administration.BMC neurology · 2019Article
- Neurobiological perspective of 22q11.2 deletion syndrome.The lancet. Psychiatry · 2019Review
- Drug-induced movement disorder and confusion associated with duloxetine.BMJ case reports · 2018Article
- Tardive Dyskinesia-like Syndrome Due to Drugs that do not Block Dopamine Receptors: Rare or Non-existent: Literature Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Review
- Disabling Resting Tremors Induced by the Short-term Infusion of Valproate: A Reversible Phenomenon.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA wide variety of movement disorders may occur as a consequence of the administration of antiepileptic drugs (AEDs). Although it has been suggested that the risk of parkinsonism is 10-fold higher in those taking valproate as compared with other AEDs, there have been no large, systematic trials assessing this.
aimTo establish more precisely the prevalence of and risk factors for developing parkinsonism associated with valproate use,and to assess the occurrence of movement disorders with the newer AEDs.
methodsPatients with epilepsy were recruited from the Toronto Western Hospital Epilepsy Clinic (University of Toronto, Toronto, Ontario, Canada). Each patient was examined by a movement disorder specialist who was blinded to the treatment status of the patient.
results201 patients were included. Postural tremor was the most common movement disorder (45%), followed by parkinsonism (4.5%). The odds of having parkinsonism were 5 times higher with valproate than with other AEDs. No single factor predicted the presence of parkinsonism; however, many (5/9) of the patients concurrently used other drugs or had comorbidities that could have caused or exacerbated parkinsonism. None of the newer AEDs were clearly associated with the presence of movement disorders; however, the numbers were too small to make a formal analysis.
conclusionAlthough the risk of parkinsonism with valproate is higher than with other AEDs, it is lower than originally reported. The cases available were not enough to accurately comment on the prevalence of movement disorders with the newer AEDs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.