ArticleBiophysical journal2006
Spreading of neutrophils: from activation to migration.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions.eLife · 2026Article
- Article
- Neutrophils actively swell to potentiate rapid migration.bioRxiv : the preprint server for biology · 2024Article
- Stages of NETosis Development upon Stimulation of Neutrophils with Activators of Different Types.International journal of molecular sciences · 2023Article
- Observing Membrane and Cell Adhesion via Reflection Interference Contrast Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Engineering physical microenvironments to study innate immune cell biophysics.APL bioengineering · 2022Review
- Opposite responses of normal hepatocytes and hepatocellular carcinoma cells to substrate viscoelasticity.Biomaterials science · 2020Article
- T Cells on Engineered Substrates: The Impact of TCR Clustering Is Enhanced by LFA-1 Engagement.Frontiers in immunology · 2018Article
- A Dynamic Biochemomechanical Model of Geometry-Confined Cell Spreading.Biophysical journal · 2017Article
- Neutrophil Microparticles Deliver Active Myeloperoxidase to Injured Mucosa To Inhibit Epithelial Wound Healing.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Immobilized IL-8 Triggers Phagocytosis and Dynamic Changes in Membrane Microtopology in Human Neutrophils.Annals of biomedical engineering · 2015Article
- Protrusive and Contractile Forces of Spreading Human Neutrophils.Biophysical journal · 2015Article
- Ligand-mediated friction determines morphodynamics of spreading T cells.Biophysical journal · 2014Article
- Serum amyloid P: a systemic regulator of the innate immune response.Journal of leukocyte biology · 2014Review
- Agonist leukadherin-1 increases CD11b/CD18-dependent adhesion via membrane tethers.Biophysical journal · 2013Article
- Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα.ACS nano · 2013Article
- Serum amyloid P inhibits granulocyte adhesion.Fibrogenesis & tissue repair · 2013Article
- Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy images.Nano letters · 2013Article
- Label-free characterization of living human induced pluripotent stem cells by subcellular topographic imaging technique using full-field quantitative phase microscopy coupled with interference reflection microscopy.Biomedical optics express · 2012Article
- Membrane dynamics correlate with formation of signaling clusters during cell spreading.Biophysical journal · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Neutrophils rely on rapid changes in morphology to ward off invaders. Time-resolved dynamics of spreading human neutrophils after activation by the chemoattractant fMLF (formyl methionyl leucyl phenylalanine) was observed by RICM (reflection interference contrast microscopy). An image-processing algorithm was developed to identify the changes in the overall cell shape and the zones of close contact with the substrate. We show that in the case of neutrophils, cell spreading immediately after exposure of fMLF is anisotropic and directional. The dependence of spreading area, A, of the cell as a function of time, t, shows several distinct regimes, each of which can be fitted as power laws (A ~ t(b)). The different spreading regimes correspond to distinct values of the exponent b and are related to the adhesion state of the cell. Treatment with cytochalasin-B eliminated the anisotropy in the spreading.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.