ArticleBiophysical journal2006
A voltage-sensor water pore.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Membrane-Traversing Peptides: Mechanistic Landscapes, Assays, and Applications.Chemical reviews · 2026Review
- Multiscale modeling shows that dielectric differences make NaV channels faster than KV channels.The Journal of general physiology · 2021Article
- Insights on small molecule binding to the Hv1 proton channel from free energy calculations with molecular dynamics simulations.Scientific reports · 2020Article
- Roles for Countercharge in the Voltage Sensor Domain of Ion Channels.Frontiers in pharmacology · 2020Review
- Molecular Dynamics Simulation for All.Neuron · 2018Review
- Does Proton Conduction in the Voltage-Gated HThe journal of physical chemistry. B · 2017Article
- The Hv1 proton channel responds to mechanical stimuli.The Journal of general physiology · 2016Article
- Article
- Mechanism Matters: A Taxonomy of Cell Penetrating Peptides.Trends in biochemical sciences · 2015Review
- Structural and Thermodynamic Insight into Spontaneous Membrane-Translocating Peptides Across Model PC/PG Lipid Bilayers.The Journal of membrane biology · 2015Article
- Voltage Sensing in Membranes: From Macroscopic Currents to Molecular Motions.The Journal of membrane biology · 2015Review
- Electric fingerprint of voltage sensor domains.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Implicit membrane treatment of buried charged groups: application to peptide translocation across lipid bilayers.Biochimica et biophysica acta · 2014Article
- Evolutionary imprint of activation: the design principles of VSDs.The Journal of general physiology · 2014Article
- Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family.Physiological reviews · 2013Review
- Construction and validation of a homology model of the human voltage-gated proton channel hHV1.The Journal of general physiology · 2013Article
- Modeling and simulation of ion channels.Chemical reviews · 2012Review
- Gating pore currents and the resting state of Nav1.4 voltage sensor domains.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Structural interactions between lipids, water and S1-S4 voltage-sensing domains.Journal of molecular biology · 2012Article
- The influence of lipids on voltage-gated ion channels.Current opinion in structural biology · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Voltage-sensor (VS) domains cause the pore of voltage-gated ion channels to open and close in response to changes in transmembrane potential. Recent experimental studies suggest that VS domains are independent structural units. This independence is revealed dramatically by a voltage-dependent proton-selective channel (Hv), which has a sequence homologous to the VS domains of voltage-gated potassium channels (Kv). Here we show by means of molecular dynamics simulations that the isolated open-state VS domain of the KvAP channel in a lipid membrane has a configuration consistent with a water channel, which we propose as a common feature underlying the conductance of protons, and perhaps other cations, through VS domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.