Trial reportAddictive behaviors2007
The reinforcing, subject-rated, performance, and cardiovascular effects of d-amphetamine: influence of sensation-seeking status.
Trial report in Addictive behaviors, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic reviews of the acute effects of amphetamine on working memory and other cognitive performances in healthy individuals, with a focus on the potential influence of personality traits.Human psychopharmacology · 2023Pooled it
- The effects of caffeine and d-amphetamine on spatial span task in healthy participants.PloS one · 2023Trial
- Acute drug effects differentially predict desire to take dextroamphetamine again for work and recreation.Psychopharmacology · 2021Trial
- Individual differences in the reinforcing and subjective effects of d-amphetamine: Dimensions of impulsivity.Experimental and clinical psychopharmacology · 2016Trial
- Dopamine modulates risk-taking as a function of baseline sensation-seeking trait.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Trial
- Personality and the acute subjective effects of d-amphetamine in humans.Journal of psychopharmacology (Oxford, England) · 2013Trial
- The amphetamine response moderates the relationship between negative emotionality and alcohol use.Alcoholism, clinical and experimental research · 2013Trial
- Sensation seeking predicts brain responses in the old-new task: converging multimodal neuroimaging evidence.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2012Trial
- Effects of 24 hours of tobacco withdrawal and subsequent tobacco smoking among low and high sensation seekers.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2011Trial
- Comparison of the behavioral and cardiovascular effects of intranasal and oral d-amphetamine in healthy human subjects.Journal of clinical pharmacology · 2011Trial
- A randomized, placebo-controlled trial of sustained-release dextroamphetamine for treatment of methamphetamine addiction.Clinical pharmacology and therapeutics · 2011Trial
- Performance and subjective effects of diazepam and d-amphetamine in high and low sensation seekers.Behavioural pharmacology · 2009Trial
- Reinforcing and subjective effects of methylphenidate in adults with and without attention deficit hyperactivity disorder (ADHD).Psychopharmacology · 2009Trial
- SELF-Tree: An Interpretable Model for Multivariate Causal Direction Heterogeneity Analysis.Psychometrika · 2026Article
- The mesocorticolimbic system in stimulant use disorder.Molecular psychiatry · 2025Review
- Contextual and psychosocial factors influencing drug reward in humans: The importance of non-drug reinforcement.Pharmacology, biochemistry, and behavior · 2024Review
- Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation.Scientific reports · 2024Article
- On the learning of addictive behavior: Sensation-seeking propensity predicts dopamine turnover in dorsal striatum.Brain imaging and behavior · 2022Article
- Subjective responses predict d-amphetamine choice in healthy volunteers.Pharmacology, biochemistry, and behavior · 2021Article
- Developmental differences in reward sensitivity and sensation seeking in adolescence: Testing sex-specific associations with gonadal hormones and pubertal development.Journal of personality and social psychology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Individual differences that may contribute to vulnerability to abuse drugs have been identified. Sensation-seeking status has been shown to influence both vulnerability to drug use and response to acute drug administration. The purpose of the present experiment was to examine the reinforcing effects of d-amphetamine in high and low sensation-seeking subjects using a modified progressive-ratio procedure. A battery of subject-rated, performance, and cardiovascular measures was also included to better characterize the effects of d-amphetamine in these groups. Ten high sensation seekers and ten low sensation seekers that were matched for education, age, drug use, height, and weight, first sampled doses of d-amphetamine (0, 8, and 16 mg). In subsequent sessions, subjects were offered the opportunity to work for the sampled dose on a modified progressive-ratio procedure. d-Amphetamine functioned as a reinforcer and produced prototypical stimulant-like effects (e.g., increased subject-ratings of Like Drug, enhanced performance, and increased heart rate). High sensation seekers were more sensitive than low sensation seekers to the reinforcing and some of the subject-rated effects of d-amphetamine. The results of the present experiment extend those of previous findings by demonstrating that the reinforcing effects of d-amphetamine vary as a function of the biologically based sensation-seeking personality trait. These results suggest that increased stimulant drug use and abuse among high sensation seekers may be related, in part, to increased sensitivity to the reinforcing effects of stimulants among these individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.