ArticleGenome biology2006
Ancient genomic architecture for mammalian olfactory receptor clusters.
Article in Genome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 55 citations in OpenAlex.
- Article
- Measures of Homozygosity and Relationship to Genetic Diversity in the Bearded Collie Breed.Genes · 2025Article
- A unified nomenclature for vertebrate olfactory receptors.BMC evolutionary biology · 2020Article
- Therapeutic potential of ectopic olfactory and taste receptors.Nature reviews. Drug discovery · 2019Review
- The best smellers make the best choosers: mate choice is affected by female chemosensory receptor gene diversity in a mammal.Proceedings. Biological sciences · 2018Article
- The Birth and Death of Olfactory Receptor Gene Families in Mammalian Niche Adaptation.Molecular biology and evolution · 2018Article
- When the Nose Doesn't Know: Canine Olfactory Function Associated With Health, Management, and Potential Links to Microbiota.Frontiers in veterinary science · 2018Review
- ORDB, HORDE, ODORactor and other on-line knowledge resources of olfactory receptor-odorant interactions.Database : the journal of biological databases and curation · 2016Article
- Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals.Genome research · 2014Article
- Implications of human genome structural heterogeneity: functionally related genes tend to reside in organizationally similar genomic regions.BMC genomics · 2014Article
- Genome analysis of the domestic dog (Korean Jindo) by massively parallel sequencing.DNA research : an international journal for rapid publication of reports on genes and genomes · 2012Article
- Promoter architecture of mouse olfactory receptor genes.Genome research · 2012Article
- WordCluster: detecting clusters of DNA words and genomic elements.Algorithms for molecular biology : AMB · 2011Article
- Map formation in the olfactory bulb by axon guidance of olfactory neurons.Frontiers in systems neuroscience · 2011Article
- Genomic architecture of MHC-linked odorant receptor gene repertoires among 16 vertebrate species.Immunogenetics · 2010Review
- Plasticity of the chemoreceptor repertoire in Drosophila melanogaster.PLoS genetics · 2009Article
- Common peptides shed light on evolution of Olfactory Receptors.BMC evolutionary biology · 2009Article
- Cryptic preference for MHC-dissimilar females in male red junglefowl, Gallus gallus.Proceedings. Biological sciences · 2009Article
- Computational Biology of Olfactory Receptors.Current bioinformatics · 2009Article
- Update on the olfactory receptor (OR) gene superfamily.Human genomics · 2008Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMammalian olfactory receptor (OR) genes reside in numerous genomic clusters of up to several dozen genes. Whole-genome sequence alignment nets of five mammals allow their comprehensive comparison, aimed at reconstructing the ancestral olfactory subgenome.
resultsWe developed a new and general tool for genome-wide definition of genomic gene clusters conserved in multiple species. Syntenic orthologs, defined as gene pairs showing conservation of both genomic location and coding sequence, were subjected to a graph theory algorithm for discovering CLICs (clusters in conservation). When applied to ORs in five mammals, including the marsupial opossum, more than 90% of the OR genes were found within a framework of 48 multi-species CLICs, invoking a general conservation of gene order and composition. A detailed analysis of individual CLICs revealed multiple differences among species, interpretable through species-specific genomic rearrangements and reflecting complex mammalian evolutionary dynamics. One significant instance involves CLIC #1, which lacks a human member, implying the human-specific deletion of an OR cluster, whose mouse counterpart has been tentatively associated with isovaleric acid odorant detection.
conclusionThe identified multi-species CLICs demonstrate that most of the mammalian OR clusters have a common ancestry, preceding the split between marsupials and placental mammals. However, only two of these CLICs were capable of incorporating chicken OR genes, parsimoniously implying that all other CLICs emerged subsequent to the avian-mammalian divergence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.