ArticleBMC cancer2006
Eukaryotic initiation factor 4E (eIF4E) and angiogenesis: prognostic markers for breast cancer.
Article in BMC cancer, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials.Annals of oncology : official journal of the European Society for Medical Oncology · 2017Trial
- Reciprocal Dynamics of Metabolism and mRNA Translation in Tumor Angiogenesis.International journal of molecular sciences · 2024Review
- Study of angiogenesis in invasive breast carcinoma by morphometry and immunohistochemistry.Medical journal, Armed Forces India · 2022Article
- The function and regulatory mechanism of RNA-binding proteins in breast cancer and their future clinical treatment prospects.Frontiers in oncology · 2022Review
- Nucleotide-decorated AuNPs as probes for nucleotide-binding proteins.Scientific reports · 2021Article
- Novel AU-rich proximal UTR sequences (APS) enhance CXCL8 synthesis upon the induction of rpS6 phosphorylation.PLoS genetics · 2019Article
- The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis.Cancers · 2019Article
- Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development.Frontiers in oncology · 2017Review
- Expression of phosphorylated eIF4E-binding protein 1, but not of eIF4E itself, predicts survival in male breast cancer.British journal of cancer · 2016Article
- A Set of miRNAs, Their Gene and Protein Targets and Stromal Genes Distinguish Early from Late Onset ER Positive Breast Cancer.PloS one · 2016Article
- Targeting the eIF4F translation initiation complex: a critical nexus for cancer development.Cancer research · 2015Review
- Enterococcus faecalis from healthy infants modulates inflammation through MAPK signaling pathways.PloS one · 2014Article
- Detection of eukaryotic translation initiation factor 4E and its clinical significance in hepatocellular carcinoma.World journal of gastroenterology · 2012Article
- Estimation of immunohistochemical expression of VEGF in ductal carcinomas of the breast.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2011Article
- Breast Tumor Angiogenesis and Tumor-Associated Macrophages: Histopathologist's Perspective.Pathology research international · 2011Article
- Differential regulation of oestrogen receptor β isoforms by 5' untranslated regions in cancer.Journal of cellular and molecular medicine · 2010Article
- Relationship and prognostic significance of SPARC and VEGF protein expression in colon cancer.Journal of experimental & clinical cancer research : CR · 2010Article
- Combining neuropeptide Y and mesenchymal stem cells reverses remodeling after myocardial infarction.American journal of physiology. Heart and circulatory physiology · 2010Article
- Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity.British journal of cancer · 2009Article
- Chemokines: novel targets for breast cancer metastasis.Cancer metastasis reviews · 2007Review
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4 authors.
Funding
Abstract
backgroundThe overexpression of eukaryotic translation initiation factor 4E (eIF4E), a key regulator of protein synthesis, is involved in the malignant progression of human breast cancer. This study investigates the relationship between eIF4E and angiogenesis, as well as their prognostic impact in patients with human breast cancer.
methodsImmunohistochemical staining was used to determine protein expression of eIF4E, vascular endothelial growth factor (VEGF), interleukin-8 (IL-8), and CD105 in a set of 122 formalin-fixed, paraffin-embedded primary breast cancer tissues. Expression of eIF4E in positive cells was characterized by cytoplasmic staining. Evaluation of VEGF and IL-8 in the same tissue established the angiogenic profiles, while CD105 was used as an indicator of microvessel density (MVD).
resultsA significant relationship was found between the level of eIF4E expression and histological grade (P = 0.016). VEGF, IL-8, and MVD were closely related to tumor grade (P = 0.003, P = 0.022, and P < 0.001, respectively) and clinical stage (P = 0.007, P = 0.048, and P < 0.001, respectively). Expression of eIF4E was also significantly correlated with VEGF (P = 0.007), IL-8 (P = 0.007), and MVD (P = 0.006). Patients overexpressing eIF4E had significantly worse overall (P = 0.01) and disease-free survival (P = 0.006). When eIF4E, histological grade, tumor stage, ER, PR, Her-2 status and the levels of VEGF, IL-8, MVD were included in a multivariate Cox regression analysis, eIF4E emerged as an independent prognostic factor for breast cancer (P = 0.001), along with stage (P = 0.005), node status (P = 0.046), and MVD (P = 0.004).
conclusionThese results suggest that higher eIF4E expression correlates with both angiogenesis and vascular invasion of cancer cells, and could therefore serve as a useful histological predictor for less favorable outcome in breast cancer patients, as well as represent a potential therapeutic target.
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