SynthesisBritish journal of clinical pharmacology2006
The effect of St John's wort extracts on CYP3A: a systematic review of prospective clinical trials.
Synthesis in British journal of clinical pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 119 citations in OpenAlex.
- Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance.Phytotherapy research : PTR · 2018Pooled it
- St John's wort for major depression.The Cochrane database of systematic reviews · 2008Pooled it
- St John's wort extract (Ze 117) does not alter the pharmacokinetics of a low-dose oral contraceptive.European journal of clinical pharmacology · 2009Trial
- No clinically relevant CYP3A induction after St. John's wort with low hyperforin content in healthy volunteers.European journal of clinical pharmacology · 2009Trial
- Hyperforin as a Multifunctional Specialized Metabolite of Natural Origin for Chronic Diseases: From Molecular Mechanisms to Clinical Translation.Current issues in molecular biology · 2026Review
- Predicting Food-Drug Interactions between Piperine and CYP3A4 Substrate Drugs Using PBPK Modeling.International journal of molecular sciences · 2024Article
- Differences in the Perception of Dietary Supplements between Dietary Supplement/Medicine Users and Non-Users.Nutrients · 2022Article
- Biocompatible Core-Shell-Structured Si-Based NiO Nanoflowers and Their Anticancer Activity.Pharmaceutics · 2022Article
- Article
- Clinical relevance of St. John's wort drug interactions revisited.British journal of pharmacology · 2020Review
- No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein.Clinical pharmacology and therapeutics · 2019Article
- Phytomedicines in the Treatment of Migraine.CNS drugs · 2019Review
- Can Foods or Herbs Alter the Bioavailability of Chemotherapy Drugs?ACS pharmacology & translational science · 2019Article
- Adverse Effects of Nutraceuticals and Dietary Supplements.Annual review of pharmacology and toxicology · 2018Review
- St John's wort (Hypericum perforatum)-induced psychosis: a case report.Journal of medical case reports · 2017Article
- Pharmacokinetic Interactions between Drugs and Botanical Dietary Supplements.Drug metabolism and disposition: the biological fate of chemicals · 2016Review
- A review of significant pharmacokinetic drug interactions with antidepressants and their management.The mental health clinician · 2016Review
- Quality and safety of herbal medical products: regulation and the need for quality assurance along the value chains.British journal of clinical pharmacology · 2015Review
- Depression in cancer patients: Pathogenesis, implications and treatment (Review).Oncology letters · 2015Article
- Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality?Journal of traditional and complementary medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this systematic review was to assess the quality and outcomes of clinical trials investigating the effect of St John's wort extracts on the metabolism of drugs by CYP3A.
methodsProspective clinical trials assessing the effect of St John's wort (SJW) extracts on metabolism by CYP3A were identified through computer-based searches (from their inception to May 2005) of Medline, Cinahl, PsycINFO, AMED, Current Contents and Embase, hand-searches of bibliographies of relevant papers and consultation with manufacturers and researchers in the field. Two reviewers selected trials for inclusion, independently extracted data and recorded details on study design.
resultsThirty-one studies met the eligibility criteria. More than two-thirds of the studies employed a before-and-after design, less than one-third of the studies used a crossover design, and only three studies were double-blind and placebo controlled. In 12 studies the SJW extract had been assayed, and 14 studies stated the specific SJW extract used. Results from 26 studies, including all of the 19 studies that used high-dose hyperforin extracts (>10 mg day(-1)), had outcomes consistent with CYP3A induction. The three studies using low-dose hyperforin extracts (<4 mg day(-1)) demonstrated no significant effect on CYP3A.
conclusionThere is reasonable evidence to suggest that high-dose hyperforin SJW extracts induce CYP3A. More studies are required to determine whether decreased CYP3A induction occurs after low-dose hyperforin extracts. Future studies should adopt study designs with a control phase or control group, identify the specific SJW extract employed and provide quantitative analyses of key constituents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.