ArticleCell stress & chaperones2006
Exogenous heat shock protein 70 mediates sepsis manifestations and decreases the mortality rate in rats.
Article in Cell stress & chaperones, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Multi-Omic blood analysis reveals differences in innate inflammatory sensitivity between species.medRxiv : the preprint server for health sciences · 2023Article
- The role of molecular chaperones in the mechanisms of epileptogenesis.Cell stress & chaperones · 2023Review
- The Effects of HBiomedicines · 2022Article
- Heat shock proteins: a history of study in Russia.Cell stress & chaperones · 2021Review
- Review
- Preventive Administration of the Heat Shock Protein Hsp70 Relieves Endotoxemia-Induced Febrile Reaction in Pigeons (Journal of evolutionary biochemistry and physiology · 2021Article
- HInflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Subcutaneous injection of recombinant heat shock protein 70 ameliorates atopic dermatitis skin lesions in a mouse model.The Kaohsiung journal of medical sciences · 2020Article
- Heat acclimation increases inflammatory and apoptotic responses to subsequent LPS challenge in C2C12 myotubes.Cell stress & chaperones · 2018Article
- Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNFα in human phagocytes.Cell stress & chaperones · 2017Article
- The development of modified human Hsp70 (HSPA1A) and its production in the milk of transgenic mice.Cell stress & chaperones · 2016Article
- Exogenous Hsp70 delays senescence and improves cognitive function in aging mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Role of Exogenous Hsp72 on Liver Dysfunction during Sepsis.BioMed research international · 2015Article
- Heat shock protein 72 expressing stress in sepsis: unbridgeable gap between animal and human studies--a hypothetical "comparative" study.BioMed research international · 2014Review
- Dynamics of endogenous Hsp70 synthesis in the brain of olfactory bulbectomized mice.Cell stress & chaperones · 2013Article
- Recombinant human Hsp70 protects against lipoteichoic acid-induced inflammation manifestations at the cellular and organismal levels.Cell stress & chaperones · 2012Article
- Hsp70 and cardiac surgery: molecular chaperone and inflammatory regulator with compartmentalized effects.Cell stress & chaperones · 2009Review
- The effect of the rate of heat storage on serum heat shock protein 72 in humans.European journal of applied physiology · 2008Article
- Exogenous heat shock proteins (HSP70) significantly inhibit endotoxin-induced activation of human neutrophils.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
- Effect of human recombinant and bovine heat shock proteins (70 kDa) on hemodynamics and hemostasis in endotoxin shock in rats.Doklady. Biochemistry and biophysicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian responses to bacterial lipopolysaccharide (LPS) from the outer membrane of Gram-negative bacteria can lead to an uncontrolled inflammatory reaction that can be deadly for the host. We checked whether heat shock protein 70 (Hsp70) protein is able to protect animals from the deleterious effects of bacterial LPS by monitoring the effect of exogenous Hsp70 injections before and after LPS administration. Our research with rats demonstrates for the first time that administration of exogeneous Hsp70 before and after LPS challenges can reduce mortality rates and modify several parameters of hemostasis and hemodynamics. Hsp70 isolated from bovine muscles showed significant protective effects against the impaired coagulation and fibrinolytic systems caused by LPS, and reduced the mortality caused by Escherichia coli and Salmonella typhimurium LPS injections significantly. Characteristically, Hsp70 preparations used in the experiments result in different effects when administered before and after an LPS challenge, and the effects of Hsp70 injections also differ significantly depending on the origin of the LPS (E coli vs S typhimurium). Based on our data, mammalian Hsp70 appears to be an attractive target in therapeutic strategies designed to stimulate endogenous protective mechanisms against many deleterious consequences of septic shock by accelerating the functional recovery of susceptible organs in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.