ArticleWorld journal of gastroenterology2006
Genotype-dependent activation or repression of HBV enhancer II by transcription factor COUP-TF1.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Transcriptional regulation of genetic variants in theThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024Article
- Establishment of stable cell lines in which the HBV genome replicates episomally for evaluation of antivirals.Archives of medical science : AMS · 2020Article
- A G-quadruplex motif in an envelope gene promoter regulates transcription and virion secretion in HBV genotype B.Nucleic acids research · 2017Article
- Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryo.Reproductive toxicology (Elmsford, N.Y.) · 2017Article
- Article
- LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activity.Scientific reports · 2016Article
- Origins and Evolution of Hepatitis B Virus and Hepatitis D Virus.Cold Spring Harbor perspectives in medicine · 2016Review
- Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha.Journal of virology · 2008Article
- Hepatitis B virus taxonomy and hepatitis B virus genotypes.World journal of gastroenterology · 2007Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo study the expression of HBV enhancer II by transcription factor COUP-TF1.
methodsIn order to study the regulation of HBV variants in the vicinity of the NRRE we cloned luciferase constructs containing the HBV enhancer II from variants and from HBV genotypes A and D and cotransfected them together with expression vectors for COUP-TF1 into HepG2 cells.
resultsOur findings show that enhancer II of HBV genotype A is also repressed by COUP-TF1. In contrast, two different enhancer II constructs of HBV genotype D were activated by COUP-TF1. The activation was independent of the NRRE because a natural variant with a deletion of nt 1763-1770 was still activated by COUP-TF1.
conclusionRegulation of transcription of the HBV genome seems to differ among HBV genomes derived from different genotypes. These differences in transcriptional control among HBV genotypes may be the molecular basis for differences in the clinical course among HBV genotypes.
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