Evidence map›Paper›PMID 17009391›Full record

ReviewWorld journal of gastroenterology2006

Probiotics and prebiotics in chronic inflammatory bowel diseases.

Julia B Ewaschuk, Levinus A Dieleman

Registry-linked trialAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06661044 (Exploiting Human Microbiota-associated in Vivo Models for Mechanistic Studies to Understand the Benefits of Dietary Fibre Supplementation in Patients With Prostate Cancer), which is not on this map. Cited by 43 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06661044 completednot on this mapstarted 2024, after this paper: background citation

Exploiting Human Microbiota-associated in Vivo Models for Mechanistic Studies to Understand the Benefits of Dietary Fibre Supplementation in Patients With Prostate Cancer

TypeobservationalSponsorUniversity of AberdeenRan2024 to 2025Enrolled6ConditionsProstate Cancer (Adenocarcinoma)
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 157 citations in OpenAlex.

  1. Pooled it
  2. Probiotics for induction of remission in Crohn's disease.The Cochrane database of systematic reviews · 2008
    Pooled it
  3. The effects of an oral supplement enriched with fish oil, prebiotics, and antioxidants on nutrition status in Crohn's disease patients.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2011
    Trial
  4. Trial
  5. Trial
  6. Article
  7. International journal of molecular sciences · 2024
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Exopolysaccharides FromFrontiers in microbiology · 2020
    Article
  20. Probiotics for Alleviating Alcoholic Liver Injury.Gastroenterology research and practice · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Julia B EwaschukCentre for Excellence for Gastrointestinal Inflammation and Immunity Research, University of Alberta, Edmonton, Alberta, T6G 2X8, Canada.
Levinus A Dieleman
University of Alberta · CA

Funding

CIHR 81396
6 · The paper itself

Abstract

The prokaryotic and eukaryotic cells of the colon exist in a highly complex, but harmonious relationship. Disturbances in this remarkable symbiosis can result in the development of inflammatory bowel diseases (IBD). Although the etiology of IBD is not entirely understood, it is known that the chronic inflammation of Crohn's disease, ulcerative colitis and chronic pouchitis are a result of an overly aggressive immune response to the commensal intestinal flora in genetically susceptible hosts. Recent studies have enhanced our ability to understand the interaction between the host and its intestinal microflora and the role the microflora plays in maintaining intestinal homeostasis. As we begin to understand the benefits conferred to the intestine by the microflora, the notion of modifying the composition of the bacterial load to improve human health has arisen. A significant body of research now exists investigating the role of probiotics and prebiotics in ameliorating chronic intestinal inflammation. This article will begin with an overview of the role of the commensal microflora in maintaining mucosal immune homeostasis, and how a dysregulated immune response to the intestinal microflora results in IBD. This will be followed by a summary of the use of probiotics and prebiotics in experimental and human IBD.

Indexed as

AnimalsBacteriaChronic DiseaseDietary CarbohydratesDietary FiberHomeostasisHumansInflammatory Bowel DiseasesIntestinesMiceProbioticsDietary CarbohydratesDietary Fiber

Identifiers

PMID17009391
PMCPMC4124400
OpenAlexW2110054785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.