ReviewEuropean radiology2007
Breast MR imaging in women at high-risk of breast cancer. Is something changing in early breast cancer detection?
Review in European radiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Clinical Practice Guideline for the prevention and early detection of breast and ovarian cancer in women from HBOC (hereditary breast and ovarian cancer) families.Wiener klinische Wochenschrift · 2015Guideline
- Evaluating the correlation between film mammography and MRI for screening women with increased breast cancer risk.Academic radiology · 2009Pooled it
- Ultrafast MRI in BI-RADS 4 Masses: The Fast Lane to Clarity.The Indian journal of radiology & imaging · 2026Article
- Clinical application of gadoterate meglumine in abbreviated dynamic contrast-enhanced magnetic resonance imaging of the breast with ultrafast imaging: a single-center retrospective study.Quantitative imaging in medicine and surgery · 2025Article
- Evaluation of Features in Probably Benign and Malignant Nonmass Enhancement in Breast MRI.International journal of breast cancer · 2024Article
- Article
- Breast cancer diagnosis using frequency decomposition of surface motion of actuated breast tissue.Frontiers in oncology · 2022Article
- Article
- Article
- The P.I.N.K. Study Approach for Supporting Personalized Risk Assessment and Early Diagnosis of Breast Cancer.International journal of environmental research and public health · 2021Article
- The Kaiser score reliably excludes malignancy in benign contrast-enhancing lesions classified as BI-RADS 4 on breast MRI high-risk screening exams.European radiology · 2020Article
- Hereditary breast cancer: screening and risk reducing surgery.Gland surgery · 2019Article
- Redefining the sensitivity of screening mammography: A review.American journal of surgery · 2019Review
- Changing Paradigms in Breast Cancer Screening: Abbreviated Breast MRI.European journal of breast health · 2019Review
- Applying a new quantitative global breast MRI feature analysis scheme to assess tumor response to chemotherapy.Journal of magnetic resonance imaging : JMRI · 2016Article
- Feature selection in computer-aided breast cancer diagnosis via dynamic contrast-enhanced magnetic resonance images.Journal of digital imaging · 2013Article
- The use of magnetic resonance mammography in women at increased risk for developing breast cancer.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2013Article
- A similarity study of content-based image retrieval system for breast cancer using decision tree.Medical physics · 2013Article
- Contrast enhancement kinetics of normal breast parenchyma in dynamic MR mammography: effects of menopausal status, oral contraceptives, and postmenopausal hormone therapy.European radiology · 2012Article
- [Guideline for the prevention and early detection of breast and ovarian cancer in high risk patients, particularly in women from HBOC (hereditary breast and ovarian cancer) families].Wiener klinische Wochenschrift · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the last few years, several papers have addressed the introduction of contrast-enhanced MR imaging for screening women at high risk for breast cancer. Taking in consideration five prospective studies, on 3,571 screened women with hereditary predisposition to the disease and 9,652 rounds, we found that 168 patients were diagnosed with breast cancer (155 screen-detected, eight interval, and five cancers excluded from analysis) with a detection rate per year of 1.7%. These cancers were small (49% equal to or less than 10 mm in diameter) but aggressive, 82% being invasive and 49% with histologic grade 3; however, only 19% of these invasive cancers were associated with nodal involvement. The pooled sensitivity was 16% for clinical breast examination, 40% for mammography, 43% for ultrasound, and 81% for MR. The positive predictive value (calculated on the basis of the number of invasive diagnostic procedures due to false positives) was 33%, 47%, 18%, and 53%, respectively. Aim of the present article is to present the historical development of MR imaging of breast tumors that made this application theoretically and technically possible, to explain what strategic problems we face in the presence of a hereditary predisposition to the disease, to review the main results of the published studies, and to outline open problems and future perspectives.
Indexed as
Identifiers
17008989What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.