ArticleBlood2007
Commonly dysregulated genes in murine APL cells.
Article in Blood, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
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- Notch signaling in acute promyelocytic leukemia.Leukemia · 2013Article
- The PML-Interacting Protein DAXX: Histone Loading Gets into the Picture.Frontiers in oncology · 2013Article
- Expression and function of PML-RARA in the hematopoietic progenitor cells of Ctsg-PML-RARA mice.PloS one · 2012Article
- PML-RARA can increase hematopoietic self-renewal without causing a myeloproliferative disease in mice.The Journal of clinical investigation · 2011Article
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- Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice.Blood · 2011Article
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- Specification of the NF-kappaB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKK epsilon.Nucleic acids research · 2010Article
- Effects of the NUP98-DDX10 oncogene on primary human CD34+ cells: role of a conserved helicase motif.Leukemia · 2010Article
- Clara cells attenuate the inflammatory response through regulation of macrophage behavior.American journal of respiratory cell and molecular biology · 2010Article
- Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100.Blood · 2009Article
- High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.The Journal of clinical investigation · 2009Article
- A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects.Blood · 2009Review
- Applications of microarray technology to Acute Myelogenous Leukemia.Cancer informatics · 2009Article
- Article
- Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia.Genome biology · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
To identify genes that are commonly dysregulated in a murine model of acute promyelocytic leukemia (APL), we first defined gene expression patterns during normal murine myeloid development; serial gene expression profiling studies were performed with primary murine hematopoietic progenitors that were induced to undergo myeloid maturation in vitro with G-CSF. Many genes were reproducibly expressed in restricted developmental "windows," suggesting a structured hierarchy of expression that is relevant for the induction of developmental fates and/or differentiated cell functions. We compared the normal myeloid developmental transcriptome with that of APL cells derived from mice expressing PML-RARalpha under control of the murine cathepsin G locus. While many promyelocyte-specific genes were highly expressed in all APL samples, 116 genes were reproducibly dysregulated in many independent APL samples, including Fos, Jun, Egr1, Tnf, and Vcam1. However, this set of commonly dysregulated genes was expressed normally in preleukemic, early myeloid cells from the same mouse model, suggesting that dysregulation occurs as a "downstream" event during disease progression. These studies suggest that the genetic events that lead to APL progression may converge on common pathways that are important for leukemia pathogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.