ArticleProceedings of the National Academy of Sciences of the United States of America2006
CD8+ regulatory T cells generated by neonatal recognition of peripheral self-antigen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Development of systemic and mucosal immune responses against gut microbiota in early life and implications for the onset of allergies.Frontiers in allergy · 2024Review
- The adaptive immune system in early life: The shift makes it count.Frontiers in immunology · 2022Review
- Neonatal T Cells: A Reinterpretation.Annual review of immunology · 2020Review
- Dissecting the defects in the neonatal CD8Journal of leukocyte biology · 2019Review
- CD8EBioMedicine · 2019Article
- Neonatal influenza-specific effector CTLs retain elevated CD31 levels at the site of infection and have decreased IFN-γ production.Journal of leukocyte biology · 2019Article
- Efficient Therapeutic Function and Mechanisms of Human Polyclonal CD8Journal of immunology research · 2019Article
- Maintaining T cell tolerance of alloantigens: Lessons from animal studies.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Review
- CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses.Journal of leukocyte biology · 2018Article
- Promoting transplantation tolerance; adoptive regulatory T cell therapy.Clinical and experimental immunology · 2013Review
- Article
- Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- Regulatory immune cells in transplantation.Nature reviews. Immunology · 2012Review
- Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation.Frontiers in immunology · 2012Article
- In vitro induced CD8+ regulatory T cells inhibit skin inflammation.European journal of microbiology & immunology · 2011Article
- Generation and function of immunosuppressive human and murine CD8+ T cells by transforming growth factor-β and retinoic acid.Immunology · 2011Article
- Moving to tolerance: clinical application of T regulatory cells.Seminars in immunology · 2011Review
- Local induction of immunosuppressive CD8+ T cells in the gut-associated lymphoid tissues.PloS one · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In comparison with CD4+ regulatory T cells, the generation and function of immunomodulatory CD8+T cells is less well defined. Here we describe the existence of regulatory anti-Kb-specific CD8+ T cells that are rendered tolerant during neonatal life via antigen contact exclusively on keratinocytes. These regulatory T cells maintain tolerance during adulthood as they prevent Kb-specific graft rejection by naïve CD8+ T cells. Third-party immune responses remain unaffected. Up-regulation of TGF-beta1 and granzyme B in the regulatory CD8+ T cell population suggests the involvement of these molecules in common suppressive pathways shared with CD4+ regulatory T cells. In summary, CD8+ regulatory T cells can be induced extrathymically through antigen contact on neonatally accessible parenchymal cells and maintain tolerance throughout adult life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.