ArticleThe Journal of physiology2006
Activation of protein kinase C augments T-type Ca2+ channel activity without changing channel surface density.
Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 67 citations in OpenAlex.
- Effect of Shin'iseihaito (Xinyiqingfeitang) on MUC5AC expression in cultured pulmonary epithelial cells and the role of its component gypsum.Journal of natural medicines · 2026Article
- Interleukin-22 receptor 1-mediated stimulation of T-type CaCell communication and signaling : CCS · 2024Article
- Adiponectin receptor 1-mediated stimulation of Cav3.2 channels in trigeminal ganglion neurons induces nociceptive behaviors in mice.The journal of headache and pain · 2023Article
- Review
- Effects of progesterone on T-type-CaNeural regeneration research · 2022Article
- Ion Channel Function and Electrical Excitability in the Zona Glomerulosa: A Network Perspective on Aldosterone Regulation.Annual review of physiology · 2021Review
- The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.Frontiers in cellular neuroscience · 2020Review
- A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type CaScientific reports · 2019Article
- Inhibition of CaBritish journal of pharmacology · 2019Article
- Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia.Human molecular genetics · 2018Article
- Inhibitory peptidergic modulation ofeLife · 2017Article
- Article
- Ca-α1T, a fly T-type Ca2+ channel, negatively modulates sleep.Scientific reports · 2015Article
- Caveolin-3 Overexpression Attenuates Cardiac Hypertrophy via Inhibition of T-type Ca2+ Current Modulated by Protein Kinase Cα in Cardiomyocytes.The Journal of biological chemistry · 2015Article
- Nickel suppresses the PACAP-induced increase in guinea pig cardiac neuron excitability.American journal of physiology. Cell physiology · 2015Article
- Noradrenaline upregulates T-type calcium channels in rat pinealocytes.The Journal of physiology · 2015Article
- RNA interference of GluN1 inhibits neuronal rhythmogenesis in the adult inferior olive.Journal of molecular neuroscience : MN · 2015Article
- Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells.Neuron · 2015Article
- Article
- Nonspecific, reversible inhibition of voltage-gated calcium channels by CaMKII inhibitor CK59.Cellular and molecular neurobiology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
T-type Ca2+ channels play essential roles in numerous cellular processes. Recently, we reported that phorbol-12-myristate-13-acetate (PMA) potently enhanced the current amplitude of Cav3.2 T-type channels reconstituted in Xenopus oocytes. Here, we have compared PMA modulation of the activities of Cav3.1, Cav3.2 and Cav3.3 channels, and have investigated the underlying mechanism. PMA augmented the current amplitudes of the three T-type channel isoforms, but the fold stimulations and time courses differed. The augmentation effects were not mimicked by 4alpha-PMA, an inactive stereoisomer of PMA, but were abolished by preincubation with protein kinase C (PKC) inhibitors, indicating that PMA augmented T-type channel currents via activation of oocyte PKC. The stimulation effect on Cav3.1 channel activity by PKC was mimicked by endothelin when endothelin receptor type A was coexpressed with Cav3.1 in the Xenopus oocyte system. Pharmacological studies combined with fluorescence imaging revealed that the surface density of Cav3.1 T-type channels was not significantly changed by activation of PKC. The PKC effect on Cav3.1 was localized to the cytoplasmic II-III loop using chimeric channels with individual cytoplasmic loops of Cav3.1 replaced by those of Cav2.1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.