ArticleNeurobiology of disease2007
Signal transducers and activators of transcription 5 contributes to erythropoietin-mediated neuroprotection against hippocampal neuronal death after transient global cerebral ischemia.
Article in Neurobiology of disease, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 72 citations in OpenAlex.
- Sovateltide at the heart-brain axis crosstalk in Alzheimer's disease: a promising multi-target and cutting-edge therapeutic approach.Inflammopharmacology · 2026Review
- Neuroprotection strategies in traumatic brain injury: Studying the effectiveness of different clinical approaches.Surgical neurology international · 2024Review
- Research progress on high-concentration oxygen therapy after cerebral hemorrhage.Frontiers in neurology · 2024Review
- Inhibition of the JAK2/STAT3 pathway and cell cycle re-entry contribute to the protective effect of remote ischemic pre-conditioning of rat hindlimbs on cerebral ischemia/reperfusion injury.CNS neuroscience & therapeutics · 2023Article
- Erythropoietin regulates signaling pathways associated with neuroprotective events.Experimental brain research · 2022Review
- Photobiomodulation Improves the Inflammatory Response and Intracellular Signaling Proteins Linked to Vascular Function and Cell Survival in the Brain of Aged Rats.Molecular neurobiology · 2022Article
- Association between chronic kidney disease and Alzheimer's disease: an update.Metabolic brain disease · 2020Review
- L-Norvaline, a new therapeutic agent against Alzheimer's disease.Neural regeneration research · 2019Article
- IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms.Oncotarget · 2016Article
- rhEPO affects apoptosis in hippocampus of aging rats by upregulating SIRT1.International journal of clinical and experimental pathology · 2015Article
- Erythropoietin: emerging role of erythropoietin in neonatal neuroprotection.Pediatric neurology · 2014Review
- JAK2/STAT5/Bcl-xL signalling is essential for erythropoietin-mediated protection against apoptosis induced in PC12 cells by the amyloid β-peptide Aβ25-35.British journal of pharmacology · 2014Article
- Neuroplasticity and the next wave of antidepressant strategies.Frontiers in cellular neuroscience · 2013Review
- Erythropoietin neuroprotection with traumatic brain injury.Pathophysiology : the official journal of the International Society for Pathophysiology · 2013Article
- Antidepressant-like effects of erythropoietin: a focus on behavioural and hippocampal processes.PloS one · 2013Article
- Novel mitochondrial targets for neuroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Review
- Molecular and cellular pathways as a target of therapeutic hypothermia: pharmacological aspect.Current neuropharmacology · 2012Article
- Neuroprotective and anti-inflammatory effects of the flavonoid-enriched fraction AF4 in a mouse model of hypoxic-ischemic brain injury.PloS one · 2012Article
- Signal transducers and activators of transcription: STATs-mediated mitochondrial neuroprotection.Antioxidants & redox signaling · 2011Review
- Trophic factors and stem cells for promoting recovery in stroke.Journal of vascular and interventional neurology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The signal transducers and activators of transcription (STAT) proteins are a group of transcriptional factors. Among them, STAT5 initiates a pro-survival signaling cascade. So far, little has been known about the role of STAT5 in cerebral ischemia and reperfusion. This study examines the phosphorylation status of STAT5 in hippocampal CA1 in the early stage after transient global cerebral ischemia in rats. Our data show that the phosphorylation of STAT5 was increased in hippocampal CA1 at 1h and 3h ischemia. Taking advantage of the neuroprotective effect of erythropoietin (EPO) in CA1, we further demonstrated that the administration of EPO enhanced the phosphorylation of STAT5, with SATA5a being phosphorylated earlier. The enhanced phosphorylation of STAT5 in the EPO-treated group was accompanied by the upregulation of STAT5 downstream gene products, Bcl-xL and XIAP. Consequently, ischemic CA1 neuronal damage was attenuated by the administration of EPO. Both the enhancement of STAT5 phosphorylation and the neuroprotection rendered by EPO were blocked by Tyrphostin, a selective inhibitor for Janus kinase 2, which is an upstream kinase of STAT5. These findings suggest an association between the activation of STAT5 and CA1 neuronal survival after cerebral ischemia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.