ArticleWorld journal of gastroenterology2006
Luminal oxidants selectively modulate electrogenic ion transport in rat colon.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Alternating consumption of β-glucan and quercetin reduces mortality in mice with colorectal cancer.Food science & nutrition · 2019Article
- The Sole DNA Ligase inFrontiers in cellular and infection microbiology · 2018Article
- Hydrogen peroxide scavenger, catalase, alleviates ion transport dysfunction in murine colitis.Clinical and experimental pharmacology & physiology · 2016Article
- Divergent Transcriptional Responses to Physiological and Xenobiotic Stress in Giardia duodenalis.Antimicrobial agents and chemotherapy · 2016Article
- Protective role of 1,25(OH)2 vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice.BMC gastroenterology · 2012Article
- Ion channels in inflammation.Pflugers Archiv : European journal of physiology · 2011Review
- The Vibrio cholerae cytolysin promotes chloride secretion from intact human intestinal mucosa.PloS one · 2009Article
- Entamoeba histolytica modulates a complex repertoire of novel genes in response to oxidative and nitrosative stresses: implications for amebic pathogenesis.Cellular microbiology · 2009Article
- Role of Fyn and PI3K in H2O2-induced inhibition of apical Cl-/OH- exchange activity in human intestinal epithelial cells.The Biochemical journal · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of luminal exposure to H2O(2) and two related thiol oxidizing agents on basal and stimulated chloride secretion in native colon using electrophysiological and pharmacological approaches.
methodsUnstripped rat distal colon segments were mounted in Ussing chambers. Potential difference, calculated resistance and short-circuit current across unstripped colon segments were monitored with a dual voltage/current clamp. Paracellular permeability was assessed by measuring the mucosa-to-serosa flux of a fluorescent probe (FITC).
resultsLuminal exposure to hydrogen peroxide transitorily stimulated chloride secretion without altering barrier function. This stimulatory effect could be blocked by basolateral atropine but not indomethacin. The cysteine and methionine oxidizing compounds, phenylarsine oxide and chloramine T respectively, mimicked the effect of H2O(2), except for a drop in transcolonic resistance after 30 min. In contrast to the observed stimulatory effect on basal secretion, cAMP-stimulated electrogenic ion transport was blunted by luminal H2O(2). However, the Ca(2+)-activated response remained unchanged.
conclusionH2O(2) may be an important selective modulator of intestinal ion and water secretion in certain pathologic conditions such as inflammation or ischemia-reperfusion by multiple mechanisms.
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