ArticleWorld journal of gastroenterology2006
-765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
What it found
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Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Association between rs20417 polymorphism in cyclooxygenase-2 and gastric cancer susceptibility: Evidence from15 case-control studies.Medicine · 2019Pooled it
- Cyclooxygenase-2 polymorphisms were associated with the risk of gastric cancer: evidence from a meta-analysis based on case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Pooled it
- Pooled it
- Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: a meta-analysis.World journal of gastroenterology · 2010Pooled it
- -765G>C and 8473T>C polymorphisms of COX-2 and cancer risk: a meta-analysis based on 33 case-control studies.Molecular biology reports · 2010Pooled it
- Genetic Variations in Prostaglandin EInternational journal of molecular sciences · 2021Article
- Association of COX2 -765G>C promoter polymorphism and coronary artery disease in Korean population.Genes & genomics · 2019Article
- Biochemical pathway analysis of gastric atrophy.Gastroenterology and hepatology from bed to bench · 2018Article
- Cyclooxygenase-2 polymorphisms and breast cancer associated risk in Pakistani patients.Pathology oncology research : POR · 2015Article
- Association of PPARγ gene polymorphisms with osteoarthritis in a southeast Chinese population.Journal of genetics · 2014Article
- Lack of association between cyclooxygenase 2-765G/C gene polymorphism and breast cancer risk in Ahvaz, west-south Iran.Molecular biology reports · 2014Article
- The COX-2-1195AA Genotype Is Associated with Diffuse-Type Gastric Cancer in Korea.Gut and liver · 2012Article
- Cyclooxygenase-2 -765 G/C polymorphisms and susceptibility to hepatitis B-related liver cancer in Han Chinese population.Molecular biology reports · 2012Article
- Influence of age and gender on association between -765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk: a case-control study in Iran.Gastroenterology and hepatology from bed to bench · 2012Article
- PharmGKB summary: very important pharmacogene information for PTGS2.Pharmacogenetics and genomics · 2011Article
- Association between EGF +61A/G polymorphism and gastric cancer in Caucasians.World journal of gastroenterology · 2011Article
- Role of cyclooxygenase-2 functional gene polymorphisms in Helicobacter pylori induced gastritis and gastric atrophy.Molecular and cellular biochemistry · 2009Article
- PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma.Molecular biology reports · 2009Article
- Cyclooxygenase 2 polymorphism and colorectal cancer: -765G>C variant modifies risk associated with smoking and body mass index.World journal of gastroenterology · 2008Article
- Polymorphism of -765G > C COX-2 is a risk factor for gastric adenocarcinoma and peptic ulcer disease in addition to H pylori infection: a study from northern India.World journal of gastroenterology · 2008Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma.
methodsA cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method.
results-765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).
conclusion-765C carrier status should be considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia.
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