ReviewWorld journal of gastroenterology2006
H pylori and gastric cancer: shifting the global burden.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- A Nomogram Combining Platelet to Lymphocyte Ratio (PLR) and Systemic Inflammatory Response Index (SIRI) to Predict Patients withJournal of multidisciplinary healthcare · 2025Article
- Prognostic impact and reasons for variability by tumor location in gastric cancer.World journal of gastroenterology · 2024Article
- Analysis ofGastroenterology research · 2018Article
- Serum selenium level in patients with gastric non-cardia cancer and functional dyspepsia.Iranian journal of medical sciences · 2015Article
- ARID1A expression in gastric adenocarcinoma: clinicopathological significance and correlation with DNA mismatch repair status.World journal of gastroenterology · 2015Observational
- Ecological study of gastric cancer in Brazil: geographic and time trend analysis.World journal of gastroenterology · 2014Article
- Serum Helicobacter pylori NapA antibody as a potential biomarker for gastric cancer.Scientific reports · 2014Article
- Contribution of toll-like receptor signaling pathways to breast tumorigenesis and treatment.Breast cancer (Dove Medical Press) · 2013Review
- Histamine and histamine receptor regulation of gastrointestinal cancers.Translational gastrointestinal cancer · 2012Article
- Incidence and mortality trends of gastric and colorectal cancers in Croatia, 1988-2008.Croatian medical journal · 2012Article
- Downregulation of Id1 by small interfering RNA in gastric cancer inhibits cell growth via the Akt pathway.Molecular medicine reports · 2012Article
- Influence of age and gender on association between -765G > C COX-2 genetic polymorphism and gastric adenocarcinoma risk: a case-control study in Iran.Gastroenterology and hepatology from bed to bench · 2012Article
- Reduced FAF1 Expression and Helicobacter Infection: Correlations with Clinicopathological Features in Gastric Cancer.Gastroenterology research and practice · 2012Article
- Gastric carcinomas localized to the cardia.Gastroenterology research and practice · 2012Article
- Positive selection on a bacterial oncoprotein associated with gastric cancer.Gut pathogens · 2011Article
- The decline in stomach cancer mortality: exploration of future trends in seven European countries.European journal of epidemiology · 2011Article
- Association of IL1B -511C/-31T haplotype and Helicobacter pylori vacA genotypes with gastric ulcer and chronic gastritis.BMC gastroenterology · 2010Article
- Matrix metalloproteinase-3 promoter polymorphisms but not dupA-H. pylori correlate to duodenal ulcers in H. pylori-infected females.BMC microbiology · 2010Article
- Helicobacter pylori in dental plaque and stomach of patients from Northern Brazil.World journal of gastroenterology · 2010Article
- Diversity of VacA intermediate region among Helicobacter pylori strains from several regions of the world.Journal of clinical microbiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infection with H pylori leads to a persistent chronic inflammation of the gastric mucosa, thereby increasing the risk of distal gastric adenocarcinoma. Numerous studies have determined a clear correlation between H pylori infection and the risk of gastric cancer; however, general eradication is not recommended as cancer prophylaxis and time points for treatment remain controversial in different areas of the world. Prevalence rates in Western countries are decreasing, especially in younger people (< 10%); and a decline in distal gastric adenocarcinoma has been observed. Risk groups in Western countries still show considerably higher risk of developing cancer, especially in patients infected with cagA+ strains and in persons harboring genetic polymorphism of the IL-1B promoter (-511T/T) and the corresponding IL-1 receptor antagonist (IL-1RN*2). Thus, general eradication of all infected persons in Western countries not recommended and is limited to risk groups in order to achieve a risk reduction. In contrast, infection rates and cancer prevalence are still high in East Asian countries. A prevention strategy to treat infected persons may avoid the development of gastric cancer to a large extent and with enormous clinical importance. However, studies in China and Japan indicate that prevention of gastric cancer is effective only in those patients that do not display severe histological changes such as atrophy and intestinal metaplasia. Thus, prophylactic strategies to prevent gastric cancer in high risk populations such as China should therefore especially aim at individuals now at younger age when the histological alterations caused by the bacterial infection was still reversible. In countries with a low prevalence of gastric cancer, risk groups carrying cagA+ strains and IL-1 genetic polymorphisms should be identified and treated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.