ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Bidirectional dopaminergic modulation of excitatory synaptic transmission in orexin neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- The Antinarcolepsy Drug Modafinil Reverses Hypoglycemia Unawareness and Normalizes Glucose Sensing of Orexin Neurons in Male Mice.Diabetes · 2023Article
- A Review of Sleep and Its Disorders in Patients with Parkinson's Disease in Relation to Various Brain Structures.Frontiers in aging neuroscience · 2016Review
- The hypocretins (orexins) mediate the "phasic" components of REM sleep: A new hypothesis.Sleep science (Sao Paulo, Brazil) · 2014Article
- Effect of dopamine D1 and D2 receptor antagonism in the lateral hypothalamus on the expression and acquisition of fructose-conditioned flavor preference in rats.Brain research · 2014Article
- Intravenous prenatal nicotine exposure increases orexin expression in the lateral hypothalamus and orexin innervation of the ventral tegmental area in adult male rats.Drug and alcohol dependence · 2013Article
- The orexin-1 receptor antagonist SB-334867 decreases sympathetic responses to a moderate dose of methamphetamine and stress.Physiology & behavior · 2012Article
- Complex movement disorders at disease onset in childhood narcolepsy with cataplexy.Brain : a journal of neurology · 2011Article
- Dopamine acts as a partial agonist for α2A adrenoceptor in melanin-concentrating hormone neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Tobacco dependence, the insular cortex and the hypocretin connection.Pharmacology, biochemistry, and behavior · 2011Review
- Opposite roles of dopamine and orexin in quinpirole-induced excessive drinking: a rat model of psychotic polydipsia.Psychopharmacology · 2010Article
- ATP-sensitive potassium channel-mediated lactate effect on orexin neurons: implications for brain energetics during arousal.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of alpha1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Differential effects of acute and chronic ethanol exposure on orexin expression in the perifornical lateral hypothalamus.Alcoholism, clinical and experimental research · 2010Article
- Review
- Ethanol enhances glutamate transmission by retrograde dopamine signaling in a postsynaptic neuron/synaptic bouton preparation from the ventral tegmental area.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2009Article
- Steady-state methadone blocks cocaine seeking and cocaine-induced gene expression alterations in the rat brain.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2009Article
- Dopamine and aging: intersecting facets.Neurochemical research · 2009Review
- Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Sleep deprivation decreases binding of [11C]raclopride to dopamine D2/D3 receptors in the human brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Food restriction alters N'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine dihydrochloride (pramipexole)-induced yawning, hypothermia, and locomotor activity in rats: evidence for sensitization of dopamine D2 receptor-mediated effects.The Journal of pharmacology and experimental therapeutics · 2008Article
Corrections and comments
- Retraction · 2012-07-27Investigation by Company/Institution · Unreliable Data · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orexin neurons in the lateral hypothalamus (LH)/perifornical area (PFA) are known to promote food intake as well as provide excitatory influence on the dopaminergic reward pathway. Dopamine (DA), in turn, inhibits the reward pathway and food intake through its action in the LH/PFA. However, the cellular mechanism by which DA modulates orexin neurons remains largely unknown. Therefore, we examined the effect of DA on the excitatory neurotransmission to orexin neurons. Whole-cell patch-clamp recordings were performed using acute rat hypothalamic slices, and orexin neurons were identified by their electrophysiological and immunohistochemical characteristics. Pharmacologically isolated action potential-independent miniature EPSCs (mEPSCs) were monitored. Bath application of DA induced a bidirectional effect on the excitatory synaptic transmission dose dependently. A low dose of DA (1 microM) increased mEPSC frequency, which was blocked by the D1-like receptor antagonist SCH 23390, and mimicked by the D1-like receptor agonist SKF 81297. In contrast, higher doses of DA (10-100 microM) decreased mEPSC frequency, which could be blocked with the D2-like receptor antagonist, sulpiride. Quinpirole, the D2-like receptor agonist, also reduced mEPSC frequency. None of these compounds affected the mEPSCs amplitude, suggesting the locus of action was presynaptic. Furthermore, DA (1 microM) induced an increase in the action potential firing, whereas DA (100 microM) hyperpolarized and ceased the firing of orexin neurons, indicating the effect of DA on excitatory synaptic transmission may influence the activity of the postsynaptic cell. In conclusion, our results suggest that D1- and D2-like receptors have opposing effects on the excitatory presynaptic terminals impinging onto orexin neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.