ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Locus ceruleus regulates sensory encoding by neurons and networks in waking animals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 117 citations in OpenAlex.
- Locus coeruleus activation transforms cortical taste representations.Cell reports · 2026Article
- Early life stress induces sex-specific changes in cognitive and affective behavior associated with disrupted noradrenergic physiology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Sensory-to-motor transformations: From serial pipelines to dynamic, distributed processes.Neuroscience and biobehavioral reviews · 2026Review
- Quantitative pupillometry as a marker of autonomic dysregulation in vestibular migraine.Journal of oral & facial pain and headache · 2026Article
- Phasic and tonic arousal distinctly shape human decision bias.Communications biology · 2026Article
- Sensory adaptation supports flexible evidence accumulation during perceptual decision making.bioRxiv : the preprint server for biology · 2026Article
- Through Massage to the Brain-Neuronal and Neuroplastic Mechanisms of Massage Based on Various Neuroimaging Techniques (EEG, fMRI, and fNIRS).Journal of clinical medicine · 2026Review
- Behavioral state-dependent norepinephrine dynamics in the primary somatosensory and prefrontal cortices during tactile detection tasks.bioRxiv : the preprint server for biology · 2026Article
- Association Between Interictal Sensory Hypersensitivities and Vestibular Symptoms in Migraine: A Cross-Sectional Study.Brain and behavior · 2025Article
- Heterogeneous Effects of Cognitive Arousal on the Contrast Response in Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Noradrenaline Regulation of Brain-Body Communication.Advances in experimental medicine and biology · 2025Review
- Impaired modulation of the trigeminal caudal nucleus by the locus coeruleus in diabetic mice: the role of GABAergic and glycinergic neurons.Frontiers in neuroanatomy · 2025Article
- Transcranial Alternating Current Stimulation over Frontal Eye Fields Mimics Attentional Modulation of Visual Processing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Activation of Beta-adrenergic Receptors Upregulates the Signal-to-Noise Ratio of Auditory Input in the Medial Prefrontal Cortex and Mediates Auditory Fear Conditioning.Molecular neurobiology · 2024Article
- Optimization of Temporal Coding of Tactile Information in Rat Thalamus by Locus Coeruleus Activation.Biology · 2024Article
- Expression and localization of αEuropean journal of histochemistry : EJH · 2023Article
- The locus coeruleus mediates behavioral flexibility.Cell reports · 2022Article
- Natural locus coeruleus dynamics during feeding.Science advances · 2022Article
- The Neuromodulatory Role of the Noradrenergic and Cholinergic Systems and Their Interplay in Cognitive Functions: A Focused Review.Brain sciences · 2022Review
12 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Substantial evidence indicates that the locus ceruleus (LC)-norepinephrine (NE) projection system regulates behavioral state and state-dependent processing of sensory information. Tonic LC discharge (0.1-5.0 Hz) is correlated with levels of arousal and demonstrates an optimal firing rate during good performance in a sustained attention task. In addition, studies have shown that locally applied NE or LC stimulation can modulate the responsiveness of neurons, including those in the thalamus, to nonmonoaminergic synaptic inputs. Many recent investigations further indicate that within sensory relay circuits of the thalamus both general and specific features of sensory information are represented within the collective firing patterns of like-modality neurons. However, no studies have examined the impact of NE or LC output on the discharge properties of ensembles of functionally related cells in intact, conscious animals. Here, we provide evidence linking LC neuronal discharge and NE efflux with LC-mediated modulation of single-neuron and neuronal ensemble representations of sensory stimuli in the ventral posteriomedial thalamus of waking rats. As such, the current study provides evidence that output from the LC across a physiologic range modulates single thalamic neuron responsiveness to synaptic input and representation of sensory information across ensembles of thalamic neurons in a manner that is consistent with the well documented actions of LC output on cognition.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.