Evidence map›Paper›PMID 17005844›Full record

ArticleAntimicrobial agents and chemotherapy2006

Standardization of an experimental murine model of invasive pulmonary aspergillosis.

Donald C Sheppard, John R Graybill, Laura K Najvar, Lisa Y Chiang, Thomas Doedt, William R Kirkpatrick, Rosie Bocanegra, Ana C Vallor, Thomas F Patterson, Scott G Filler

Abstract readEvaluation Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Assessment of Antifungal Pharmacodynamics.Journal of fungi (Basel, Switzerland) · 2023
    Article
  4. Article
  5. Targeting a critical step in fungal hexosamine biosynthesis.The Journal of biological chemistry · 2020
    Article
  6. A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states.Translational research : the journal of laboratory and clinical medicine · 2020
    Article
  7. What Are the Functions of Chitin Deacetylases inFrontiers in cellular and infection microbiology · 2020
    Article
  8. Aspergillus fumigatus and Aspergillosis in 2019.Clinical microbiology reviews · 2019
    Review
  9. Article
  10. Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017
    Review
  11. Article
  12. Overview of vertebrate animal models of fungal infection.Journal of immunological methods · 2014
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Donald C SheppardMcGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada. donald.sheppard@mcgill.ca
John R Graybill
Laura K Najvar
Lisa Y Chiang
Thomas Doedt
William R Kirkpatrick
Rosie Bocanegra
Ana C Vallor
Thomas F Patterson
Scott G Filler

Funding

Transcriptional regulation of A. fumigatus virulenceR01AI073829 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G · 2007 to 2015
$2.8M
NIAID NIH HHS N01 AI030041NIAID NIH HHS R01 AI073829
6 · The paper itself

Abstract

Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

Indexed as

AspergillosisDisease Models, AnimalLung Diseases, FungalAmphotericin BAnimalsAntifungal AgentsAspergillus fumigatusHumansLiposomesLungMiceReproducibility of ResultsTreatment OutcomeAmphotericin BAntifungal Agentsliposomal amphotericin BLiposomes

Identifiers

PMID17005844
PMCPMC1610079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.