ArticleAntimicrobial agents and chemotherapy2006
Efficacy of ambruticin analogs in a murine model of coccidioidomycosis.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- A General Strategy for the Synthesis of Jerangolids Enabled by π-allyl Stille Coupling.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Genetic engineering of Sorangium cellulosum reveals hidden enzymology in myxobacterial natural product biosynthesis.Nature communications · 2025Article
- Total Synthesis of Jerangolid B via spOrganic letters · 2025Article
- The Corey-Seebach Reagent in the 21st Century: A Review.Molecules (Basel, Switzerland) · 2023Review
- Current Landscape of Coccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2022Review
- Enantioselective Total Synthesis of the Putative Biosynthetic Intermediate Ambruticin J.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- The antifungal pipeline: a reality check.Nature reviews. Drug discovery · 2017Review
- Large-Scale Evaluation ofAntimicrobial agents and chemotherapy · 2017Article
- The group III two-component histidine kinase of filamentous fungi is involved in the fungicidal activity of the bacterial polyketide ambruticin.Applied and environmental microbiology · 2009Article
- The antifungal polyketide ambruticin targets the HOG pathway.Antimicrobial agents and chemotherapy · 2007Article
- Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.Antimicrobial agents and chemotherapy · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.