Evidence map›Paper›PMID 17005833›Full record

ArticleAntimicrobial agents and chemotherapy2006

Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.

Lisa Y Chiang, Daniele E Ejzykowicz, Zong-Qiang Tian, Leonard Katz, Scott G Filler

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Current Landscape of Coccidioidomycosis.Journal of fungi (Basel, Switzerland) · 2022
    Review
  2. Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017
    Review
  3. Article
  4. The antifungal polyketide ambruticin targets the HOG pathway.Antimicrobial agents and chemotherapy · 2007
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lisa Y ChiangLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Daniele E Ejzykowicz
Zong-Qiang Tian
Leonard Katz
Scott G Filler

Funding

Transcriptional regulation of A. fumigatus virulenceR01AI073829 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI FILLER, SCOTT G · 2007 to 2015
$2.8M
NIAID NIH HHS N01 AI030041NIAID NIH HHS R01 AI073829
6 · The paper itself

Abstract

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

Indexed as

Disease Models, AnimalAnimalsAntifungal AgentsAspergillosisAspergillus fumigatusDrug Evaluation, PreclinicalHumansLung Diseases, FungalMaleMiceMice, Inbred BALB CMicrobial Sensitivity TestsPyransTreatment OutcomeambruticinAntifungal AgentsPyrans

Identifiers

PMID17005833
PMCPMC1610070

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.