ArticleAntimicrobial agents and chemotherapy2006
Weak mutators can drive the evolution of fluoroquinolone resistance in Escherichia coli.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The Mechanism of Tigecycline Resistance inInternational journal of molecular sciences · 2024Article
- The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis.FEMS microbiology reviews · 2021Review
- Bacterial defenses against a natural antibiotic promote collateral resilience to clinical antibiotics.PLoS biology · 2021Article
- Heterogeneity in efflux pump expression predisposes antibiotic-resistant cells to mutation.Science (New York, N.Y.) · 2018Article
- Checks and balances? DNA replication and the cell cycle in Plasmodium.Parasites & vectors · 2018Review
- Prevalence of hypermutators among clinical Acinetobacter baumannii isolates.The Journal of antimicrobial chemotherapy · 2016Article
- Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites.PloS one · 2016Article
- Antimicrobials, stress and mutagenesis.PLoS pathogens · 2014Article
- Selection of antibiotic resistance at very low antibiotic concentrations.Upsala journal of medical sciences · 2014Review
- Bacterial evolution of antibiotic hypersensitivity.Molecular systems biology · 2013Article
- Novel Conserved Genotypes Correspond to Antibiotic Resistance Phenotypes of E. coli Clinical Isolates.PloS one · 2013Article
- Hypermutation and stress adaptation in bacteria.Journal of genetics · 2011Review
- SOS response induces persistence to fluoroquinolones in Escherichia coli.PLoS genetics · 2009Article
- Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.Antimicrobial agents and chemotherapy · 2009Article
- Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.Antimicrobial agents and chemotherapy · 2007Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weak mutators are common among clinical isolates of Escherichia coli. We show that the relative mutation rate and the "evolvability of fluoroquinolone resistance" are related by a power law slope of 1.2 over 3 orders of magnitude. Thus, even weak mutators can drive the evolution of fluoroquinolone resistance under selection pressure.
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