ArticleAntimicrobial agents and chemotherapy2006
Inhibition of filamentation can be used to treat disseminated candidiasis.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 110 citations in OpenAlex.
- The molecular mechanism of traditional Chinese medicine in the treatment of oropharyngeal candidiasis (OPC).Journal of oral microbiology · 2025Review
- The progress and future of the treatment of Candida albicans infections based on nanotechnology.Journal of nanobiotechnology · 2024Review
- Unexpected Inhibitory Effect of Octenidine Dihydrochloride onAntibiotics (Basel, Switzerland) · 2023Article
- Antifungal Activity of the Frog Skin Peptide Temporin G and Its Effect onInternational journal of molecular sciences · 2022Article
- Mechanism of Antifungal Activity by 5-Aminoimidazole-4-Carbohydrazonamide Derivatives againstAntibiotics (Basel, Switzerland) · 2021Article
- Potent Antifungal Properties of Dimeric Acylphloroglucinols fromMetabolites · 2020Article
- Natural Variation in Clinical Isolates of Candida albicans Modulates Neutrophil Responses.mSphere · 2020Article
- Virulence and biofilms as promising targets in developing antipathogenic drugs against candidiasis.Future science OA · 2020Review
- Article
- Regulation ofJournal of fungi (Basel, Switzerland) · 2019Review
- In Vitro Antifungal and Antivirulence Activities of Biologically Synthesized Ethanolic Extract of Propolis-Loaded PLGA Nanoparticles againstEvidence-based complementary and alternative medicine : eCAM · 2019Article
- Hyphal development in Candida albicans from different cell states.Current genetics · 2018Review
- Effects of Acetone Fraction FromFrontiers in microbiology · 2018Article
- Article
- Antifungal Activity of Thapsia villosa Essential Oil against Candida, Cryptococcus, Malassezia, Aspergillus and Dermatophyte Species.Molecules (Basel, Switzerland) · 2017Article
- Chemical inhibitors of Candida albicans hyphal morphogenesis target endocytosis.Scientific reports · 2017Article
- Review
- Dectin-1 is required for miR155 upregulation in murine macrophages in response to Candida albicans.Virulence · 2017Article
- Therapeutic activity of a Saccharomyces cerevisiae-based probiotic and inactivated whole yeast on vaginal candidiasis.Virulence · 2017Article
- Examination of the pathogenic potential of Candida albicans filamentous cells in an animal model of haematogenously disseminated candidiasis.FEMS yeast research · 2016Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Candida albicans remains the leading causative agent of invasive fungal infection. Although the importance of filamentation in C. albicans pathogenesis has been extensively investigated, in vivo studies to date have been unable to dissect the role of this developmental process in the establishment of infection versus the development of active disease as characterized by damage to the host leading to mortality. To address this issue, we genetically engineered a C. albicans tet-NRG1 strain in which filamentation and virulence can be modulated both in vitro and in vivo simply by the presence or absence of doxycycline (DOX): this strain enabled us, in a prior study, to demonstrate that yeast-form cells were able to infect the deep organs but caused no disease unless filamentation (induced by the addition of DOX) was allowed to occur. In the present study, we examined whether inhibiting filamentation (by withdrawing the DOX) at 24 or 48 h postinfection could serve as an effective therapeutic intervention against candidiasis. The results obtained indicate that DOX removal led to an alteration in the morphology of the infecting fungal cells and a dramatic increase in survival, but as with conventional antifungal drug therapy regimens, mortality rates increased markedly the longer this intervention was delayed. These observations reinforce the importance of invasive filamentous growth in causing the damage to the host and the lethality associated with active disease and suggest this process could be fruitfully targeted for the development of new antifungal agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.