Evidence map›Paper›PMID 17005757›Full record

ArticleJournal of clinical microbiology2006

MultiCode-RTx real-time PCR system for detection of subpopulations of K65R human immunodeficiency virus type 1 reverse transcriptase mutant viruses in clinical samples.

Evguenia S Svarovskaia, Michael J Moser, Andrew S Bae, James R Prudent, Michael D Miller, Katyna Borroto-Esoda

Abstract read
In one paragraph

Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  8. Optimization of an unnatural base pair toward natural-like replication.Journal of the American Chemical Society · 2009
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Evguenia S SvarovskaiaGilead Sciences, Inc., 4 University Place, 4611 University Drive, Durham, NC 27707, USA. jenny.svarovskaia@gilead.com
Michael J Moser
Andrew S Bae
James R Prudent
Michael D Miller
Katyna Borroto-Esoda

Funding

Detecting Early Emerging Drug-Resistant HIV PopulationsR41AI058888 · NIAID · ERAGEN BIOSCIENCES, INC. · PI PRUDENT, JAMES R. · 2004 to 2004
$350k
NIAID NIH HHS R41 AI058888
6 · The paper itself

Abstract

We report a real-time PCR assay capable of detecting drug-resistant human immunodeficiency virus type 1 reverse transcriptase K65R mutant virus at a level of 0.5% in polymorphic patient plasma specimens. Fifty-three treatment-naïve and 20 treatment-experienced specimens were successfully genotyped with the new method. Results were in agreement with population sequencing and the labor-intensive single-genome sequencing method.

Indexed as

MutationBase SequenceHIV-1HIV Reverse TranscriptaseHumansMolecular Sequence DataPolymerase Chain ReactionRNA, ViralHIV Reverse TranscriptaseRNA, Viral

Identifiers

PMID17005757
PMCPMC1698293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.