ArticleJournal of virology2006
Nuclear import defect of human immunodeficiency virus type 1 DNA flap mutants is not dependent on the viral strain or target cell type.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport (ESCRT) protein.Virologica Sinica · 2023Article
- CAR-T cell potency: from structural elements to vector backbone components.Biomarker research · 2022Review
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- Detailed Characterization of Early HIV-1 Replication Dynamics in Primary Human Macrophages.Viruses · 2018Article
- Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis.PLoS pathogens · 2017Article
- Comparative study of the transfection efficiency of commonly used viral vectors in rhesus monkey (Zoological research · 2017Article
- Quantitative analysis of the time-course of viral DNA forms during the HIV-1 life cycle.Retrovirology · 2013Article
- The importance of becoming double-stranded: Innate immunity and the kinetic model of HIV-1 central plus strand synthesis.Virology · 2013Review
- Proteomic analysis of early HIV-1 nucleoprotein complexes.Journal of proteome research · 2013Article
- The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration.International journal of biochemistry and molecular biology · 2012Article
- Yeast and the AIDS virus: the odd couple.Journal of biomedicine & biotechnology · 2012Review
- Residual HIV-1 DNA Flap-independent nuclear import of cPPT/CTS double mutant viruses does not support spreading infection.Retrovirology · 2011Article
- Interplay between HIV entry and transportin-SR2 dependency.Retrovirology · 2011Article
- Revisiting HIV-1 uncoating.Retrovirology · 2010Review
- The HIV-1 central polypurine tract functions as a second line of defense against APOBEC3G/F.Journal of virology · 2010Article
- Molecular biology of foamy viruses.Medical microbiology and immunology · 2010Review
- Analysis of the viral elements required in the nuclear import of HIV-1 DNA.Journal of virology · 2010Article
- HIV-1 exploits importin 7 to maximize nuclear import of its DNA genome.Retrovirology · 2009Article
- Cyclophilin A-dependent restriction of human immunodeficiency virus type 1 capsid mutants for infection of nondividing cells.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously established, using human immunodeficiency virus type 1 (HIV-1) strain LAI, that the HIV-1 central DNA Flap acts as a cis determinant of viral genome nuclear import. Although the impact of the DNA Flap on nuclear import has already found numerous independent confirmations in the context of lentivirus vectors, it has been claimed that it may be nonessential for infectious virus strains LAI, YU-2 (J. D. Dvorin et al., J. Virol. 76:12087-12096, 2002), HXB2, and NL4-3 (A. Limon et al., J. Virol. 76:12078-12086, 2002). We conducted a detailed analysis of virus infectivity using the provirus clones provided by the authors and analogous target cells. In contrast to published data, our results show that all cPPT mutant viruses exhibit reduced infectivity corresponding to a nuclear import defect irrespective of the viral genetic background or target cell.
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