ArticleJournal of virology2007
Analysis of a new human parechovirus allows the definition of parechovirus types and the identification of RNA structural domains.
Article in Journal of virology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed.
- Review
- Emerging RNA-centric technologies to probe RNA-protein interactions: importance in decoding the life cycle of positive sense single strand RNA viruses and antiviral discovery.Frontiers in cellular and infection microbiology · 2025Review
- Prevalence and genetic diversity of Parechovirus.Virus research · 2024Article
- Myeloid-associated differentiation marker is an essential host factor for human parechovirus PeV-A3 entry.Nature communications · 2023Article
- Viral pathogens of acute gastroenteritis in Egyptian children: role of the parechovirus.BMC infectious diseases · 2022Article
- Protein Nucleotidylylation in +ssRNA Viruses.Viruses · 2021Review
- A comparative analysis of parechovirus protein structures with other picornaviruses.Open biology · 2021Article
- Impact of virus subtype and hostRNA (New York, N.Y.) · 2020Article
- An Emerging Human Parechovirus Type 5 Causing Sepsis-Like Illness in Infants in Australia.Viruses · 2019Article
- A 2.8-Angstrom-Resolution Cryo-Electron Microscopy Structure of Human Parechovirus 3 in Complex with Fab from a Neutralizing Antibody.Journal of virology · 2019Article
- Human Parechovirus: an Increasingly Recognized Cause of Sepsis-Like Illness in Young Infants.Clinical microbiology reviews · 2018Review
- Acute and chronic disease caused by enteroviruses.Virulence · 2017Article
- Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3.Scientific reports · 2017Article
- The Complete Genome Sequence of a Human Parechovirus from a Child with Diarrhea in China Revealed Intertypic Recombination.Genome announcements · 2017Article
- An outbreak of severe infections among Australian infants caused by a novel recombinant strain of human parechovirus type 3.Scientific reports · 2017Article
- Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis.Nature communications · 2016Article
- Human Parechovirus 1 Infection Occurs via αVβ1 Integrin.PloS one · 2016Article
- Genome analysis revealed novel genotypes and recombination of the human parechoviruses prevalent in children in Eastern China.Gut pathogens · 2016Article
- Initiation of protein-primed picornavirus RNA synthesis.Virus research · 2015Review
- Picornavirus RNA polyadenylation by 3D(pol), the viral RNA-dependent RNA polymerase.Virus research · 2015Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Human parechoviruses (HPeV), members of the Parechovirus genus of Picornaviridae, are frequent pathogens but have been comparatively poorly studied, and little is known of their diversity, evolution, and molecular biology. To increase the amount of information available, we have analyzed 7 HPeV strains isolated in California between 1973 and 1992. We found that, on the basis of VP1 sequences, these fall into two genetic groups, one of which has not been previously observed, bringing the number of known groups to five. While these correlate partly with the three known serotypes, two members of the HPeV2 serotype belong to different genetic groups. In view of the growing importance of molecular techniques in diagnosis, we suggest that genotype is an important criterion for identifying viruses, and we propose that the genetic groups we have defined should be termed human parechovirus types 1 to 5. Complete nucleotide sequence analysis of two of the Californian isolates, representing two types, confirmed the identification of a new genetic group and suggested a role for recombination in parechovirus evolution. It also allowed the identification of a putative HPeV1 cis-acting replication element, which is located in the VP0 coding region, as well as the refinement of previously predicted 5' and 3' untranslated region structures. Thus, the results have significantly improved our understanding of these common pathogens.
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