ArticleSchizophrenia research2007
The relationship between sensorimotor gating and clinical improvement in acutely ill schizophrenia patients.
Article in Schizophrenia research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Meta-Analysis of Sensorimotor Gating Deficits in Patients With Schizophrenia Evaluated by Prepulse Inhibition Test.Schizophrenia bulletin · 2020Pooled it
- A pilot open label, single dose trial of fenobam in adults with fragile X syndrome.Journal of medical genetics · 2009Trial
- Prepulse inhibition of startle in adults with ADHD.Journal of psychiatric research · 2009Trial
- COMPLEX-VALUED PHASE SYNCHRONY REVEALS DIRECTIONAL COUPLING IN FMRI AND TRACKS MEDICATION EFFECTS.ArXiv · 2025Article
- The acoustic startle response in 22q11 deletion syndrome: from animal models to humans.Frontiers in neuroscience · 2025Review
- Reduced amplitude and slowed latency of the acoustic startle response in adolescents and adults with 22q11.2 deletion syndrome.Schizophrenia research · 2024Article
- Presynaptic Kainate Receptors onto Somatostatin Interneurons Are Recruited by Activity throughout Development and Contribute to Cortical Sensory Adaptation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Age-related changes in prepulse inhibition of the startle response.Frontiers in psychiatry · 2023Article
- HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits.The international journal of neuropsychopharmacology · 2021Article
- Both HIV and Tat expression decrease prepulse inhibition with further impairment by methamphetamine.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Heritability of acoustic startle magnitude and latency from the consortium on the genetics of schizophrenia.Schizophrenia research · 2020Article
- Auditory cognitive training improves prepulse inhibition in serine racemase mutant mice.Psychopharmacology · 2020Article
- Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy.Frontiers in pharmacology · 2016Review
- Reduced Prepulse Inhibition as a Biomarker of Schizophrenia.Frontiers in behavioral neuroscience · 2016Article
- Prepulse inhibition in HIV-associated neurocognitive disorders.Journal of the International Neuropsychological Society : JINS · 2013Article
- Neonatal exposure to phenobarbital potentiates schizophrenia-like behavioral outcomes in the rat.Neuropharmacology · 2012Article
- Prepulse inhibition of startle response: recent advances in human studies of psychiatric disease.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2011Article
- Heritability of acoustic startle magnitude, prepulse inhibition, and startle latency in schizophrenia and control families.Psychiatry research · 2010Article
- The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010Article
- Prepulse inhibition in fragile X syndrome: feasibility, reliability, and implications for treatment.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
It has been suggested that sensorimotor gating deficits as indexed by prepulse inhibition (PPI) of the acoustic startle reflex represent an endophenotypic marker of psychotic conditions such as schizophrenia (SCZ). This hypothesis has been questioned as several studies have found that PPI levels change with improvement in symptoms and are responsive to medications. We tested PPI in a sample of acutely decompensated schizophrenia patients who were re-tested after 2 weeks of hospital treatment. PPI was assessed at three interstimulus intervals (30, 60, and 120 ms) in 23 SCID-diagnosed SCZ patients shortly after admission to an inpatient psychiatric hospital. Eight of these patients were initially tested in a medication-free state, and all were re-tested approximately 2 weeks later after initiation or increase/change of antipsychotic medications. Symptom ratings were collected at both sessions. 20 nonpatient comparison subjects (NCS) were also tested at a 2-week interval. While SCZ patients showed lower PPI at the first session than NCS, after 2 weeks of treatment their PPI increased to levels not different than those of NCS. In contrast, the PPI of NCS remained consistent over a 2-week period. For the SCZ patients, increase in PPI was correlated with a decrease in symptom scores. Our results suggest that PPI can be improved by short-term treatment, and that improvement in sensorimotor gating is associated with treatment-related improvement of symptoms of schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.