ArticleDevelopmental biology2007
Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegans.
Article in Developmental biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Distinct functions in fertility and patterns of paternal incorporation of the histone H2A variants HTAS-1 and HTZ-1 in C. elegans.Genetics · 2026Article
- A lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis.Nature communications · 2024Article
- Article
- A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.Nature methods · 2021Article
- Reduction of mRNA export unmasks different tissue sensitivities to low mRNA levels during Caenorhabditis elegans development.PLoS genetics · 2019Article
- Article
- Function of the C. elegans T-box factor TBX-2 depends on interaction with the UNC-37/Groucho corepressor.Developmental biology · 2016Article
- Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2015Article
- Caenorhabditis elegans TBX-2 Directly Regulates Its Own Expression in a Negative Autoregulatory Loop.G3 (Bethesda, Md.) · 2015Article
- Function of the C. elegans T-box factor TBX-2 depends on SUMOylation.Cellular and molecular life sciences : CMLS · 2013Article
- The NF-Y complex negatively regulates Caenorhabditis elegans tbx-2 expression.Developmental biology · 2013Article
- The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene.Developmental biology · 2011Review
- Multiple phenotypes resulting from a mutagenesis screen for pharynx muscle mutations in Caenorhabditis elegans.PloS one · 2011Article
- Review
- Diversification of fasting regulated transcription in a cluster of duplicated nuclear hormone receptors in C. elegans.Gene expression patterns : GEP · 2010Article
- Roles of the Wnt effector POP-1/TCF in the C. elegans endomesoderm specification gene network.Developmental biology · 2010Article
- Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development.BioEssays : news and reviews in molecular, cellular and developmental biology · 2010Review
- The polycomb complex protein mes-2/E(z) promotes the transition from developmental plasticity to differentiation in C. elegans embryos.Developmental cell · 2009Article
- The molecular basis of organ formation: insights from the C. elegans foregut.Annual review of cell and developmental biology · 2009Review
- The HLH-6 transcription factor regulates C. elegans pharyngeal gland development and function.PLoS genetics · 2008Article
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2 authors.
Funding
Abstract
During organogenesis, pluripotent precursor cells acquire a defined identity such as muscle or nerve. The transition from naïve precursor towards the differentiated state is characterized by sequential waves of gene expression that are determined by regulatory transcription factors. A key question is how transcriptional circuitry dictates the succession of events that accompanies developmental competence, cell fate specification and differentiation. To address this question, we have examined how anterior muscles are established within the Caenorhabditis elegans foregut (pharynx). We find that the T-box transcription factor tbx-2 is essential to form anterior pharyngeal muscles from the ABa blastomere. In the absence of tbx-2 function, ABa-derived cells initiate development normally: they receive glp-1/Notch signaling cues, activate the T-box gene TBX-38 and express the organ selector gene PHA-4/FoxA. However, these cells subsequently arrest development, extinguish PHA-4 and fail to activate PHA-4 target genes. tbx-2 mutant cells do not undergo apoptosis and there is no evidence for adoption of an alternative fate. TBX-2 is expressed in ABa descendants and depends on activation by pha-4 and repression by components of glp-1/Notch signaling. Our analysis suggests that a positive feedback loop between tbx-2 and pha-4 is required for ABa-derived precursors to commit to pharyngeal muscle fate.
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