ReviewMolecular neurobiology2006
Central nervous system functions of PAK protein family: from spine morphogenesis to mental retardation.
Review in Molecular neurobiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Rac-maninoff and Rho-vel: The symphony of Rho-GTPase signaling at excitatory synapses.Small GTPases · 2022Article
- Neural Mechanisms Underlying Repetitive Behaviors in Rodent Models of Autism Spectrum Disorders.Frontiers in cellular neuroscience · 2020Review
- Review
- Marginal Iodine Deficiency Affects Dendritic Spine Development by Disturbing the Function of Rac1 Signaling Pathway on Cytoskeleton.Molecular neurobiology · 2017Article
- nArgBP2 regulates excitatory synapse formation by controlling dendritic spine morphology.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Parental binge alcohol abuse alters F1 generation hypothalamic gene expression in the absence of direct fetal alcohol exposure.PloS one · 2014Article
- Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling.Frontiers in pharmacology · 2013Review
- PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- p21-Activated kinase 3 (PAK3) protein regulates synaptic transmission through its interaction with the Nck2/Grb4 protein adaptor.The Journal of biological chemistry · 2011Article
- GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice.Nature medicine · 2011Article
- Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Long-term potentiation-dependent spine enlargement requires synaptic Ca2+-permeable AMPA receptors recruited by CaM-kinase I.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- The substrates of memory: defects, treatments, and enhancement.European journal of pharmacology · 2008Review
- The neurite outgrowth multiadaptor RhoGAP, NOMA-GAP, regulates neurite extension through SHP2 and Cdc42.The Journal of cell biology · 2007Article
- Evidence that long-term potentiation occurs within individual hippocampal synapses during learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Dlx transcription factors promote migration through repression of axon and dendrite growth.Neuron · 2007Article
- Changes in synaptic morphology accompany actin signaling during LTP.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The Pak1 kinase: an important regulator of neuronal morphology and function in the developing forebrain.Molecular neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several of the genes currently known to be associated, when mutated, with mental retardation, code for molecules directly involved in Rho guanosine triphosphatase (GTPase) signaling. These include PAK3, a member of the PAK protein kinase family, which are important effectors of small GTPases. In many systems, PAK kinases play crucial roles regulating complex mechanisms such as cell migration, differentiation, or survival. Their precise functions in the central nervous system remain, however, unclear. Although their activity does not seem to be required for normal brain development, several recent studies point to a possible involvement in more subtle mechanisms such as neurite outgrowth, spine morphogenesis or synapse formation, and plasticity. This article reviews this information in the light of the current knowledge available on the molecular characteristics of the different members of this family and discuss the mechanisms through which they might contribute to cognitive functions.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.