ReviewImmunologic research2006
The lymphotoxin pathway: beyond lymph node development.
Review in Immunologic research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Peripheral immune signatures associated with invasive behavior in pituitary neuroendocrine tumor: a blood-based analysis.BMC immunology · 2026Article
- Metabolic changes during evolution of Sjögren's in both an animal model and human patients.Heliyon · 2025Article
- Article
- Evaluating the transcriptional landscape and cell-cell communication networks in chronically irradiated parotid glands.iScience · 2023Article
- Control of APOBEC3B induction and cccDNA decay by NF-κB and miR-138-5p.JHEP reports : innovation in hepatology · 2021Article
- CCL21 Expression in β-Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice.Diabetes · 2019Article
- IL-4 promotes stromal cell expansion and is critical for development of a type-2, but not a type 1 immune response.European journal of immunology · 2019Article
- Inflammatory Markers in Anorexia Nervosa: An Exploratory Study.Nutrients · 2018Article
- The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies.Cold Spring Harbor perspectives in biology · 2018Review
- Herpesvirus entry mediator (HVEM) attenuates signals mediated by the lymphotoxin β receptor (LTβR) in human cells stimulated by the shared ligand LIGHT.Molecular immunology · 2014Article
- Lymphotoxin-beta receptor blockade induces inflammation and fibrosis in tolerized cardiac allografts.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012Article
- Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice.American journal of physiology. Endocrinology and metabolism · 2012Article
- Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory.Cancer immunology, immunotherapy : CII · 2012Article
- Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.PloS one · 2012Article
- How do pleiotropic kinase hubs mediate specific signaling by TNFR superfamily members?Immunological reviews · 2011Review
- Tolerance and lymphoid organ structure and function.Frontiers in immunology · 2011Article
- Review
- Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha.BMC immunology · 2008Article
- Current status of lupus genetics.Arthritis research & therapy · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first studies of mice deficient in lymphotoxin-alpha (LTalpha), LTbeta and LTbetaR revealed the seminal discovery that the LTbetaR signaling is critical for the development of lymph nodes and Peyer's patches during embryogenesis. Since these initial findings, it is increasingly appreciated that signaling through the lymphotoxin-beta receptor (LTbetaR) plays a key role in numerous biological processes in the adult animal, including the maintenance of specialized stromal cell types and the homeostatic control of chemokine expression within the lymphoid tissues. A major focus of our laboratory is to understand the relevance of LTbetaR signaling in initiating immune responses both dependent and independent of its role in maintaining the organization of lymphoid tissues. This review will therefore explore new possibilities for how this complex pathway regulates humoral and cellular immunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.