ArticleThe American journal of pathology2006
Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis.
Article in The American journal of pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
- Ferroptosis and cancer: when iron turns against tumors.Cellular and molecular life sciences : CMLS · 2025Review
- Iron as spirit of life to share under monopoly.Journal of clinical biochemistry and nutrition · 2022Article
- Genome-wide mapping of genomic DNA damage: methods and implications.Cellular and molecular life sciences : CMLS · 2021Review
- Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering.Cancers · 2020Review
- Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.Redox biology · 2020Article
- Ferroptosis at the crossroads of infection, aging and cancer.Cancer science · 2020Review
- The genomics of oxidative DNA damage, repair, and resulting mutagenesis.Computational and structural biotechnology journal · 2020Review
- Genome-Wide Adductomics Analysis Reveals Heterogeneity in the Induction and Loss of Cyclobutane Thymine Dimers across Both the Nuclear and Mitochondrial Genomes.International journal of molecular sciences · 2019Article
- Abundance of DNA adducts of 4-oxo-2-alkenals, lipid peroxidation-derived highly reactive genotoxins.Journal of clinical biochemistry and nutrition · 2018Review
- A Reduction-Based Sensor for Acrolein Conjugates with the Inexpensive Nitrobenzene as an Alternative to Monoclonal Antibody.Scientific reports · 2016Article
- Genome-wide profiling of 8-oxoguanine reveals its association with spatial positioning in nucleus.DNA research : an international journal for rapid publication of reports on genes and genomes · 2014Article
- Mysterious link between iron overload and CDKN2A/2B.Journal of clinical biochemistry and nutrition · 2011Article
- Genome-scale approaches to investigate oxidative DNA damage.Journal of clinical biochemistry and nutrition · 2010Article
- Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease.Neurobiology of disease · 2009Article
- Age-associated oxidative damage to the p62 promoter: implications for Alzheimer disease.Free radical biology & medicine · 2009Article
- Mechanisms of asbestos-induced carcinogenesis.Nagoya journal of medical science · 2009Review
- Role of iron in carcinogenesis: cancer as a ferrotoxic disease.Cancer science · 2009Review
- Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway.The American journal of pathology · 2007Article
- Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment.Cancer science · 2006Article
Corrections and comments
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Authors and funding
22 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative stress is a persistent threat to the genome and is associated with major causes of human mortality, including cancer, atherosclerosis, and aging. Here we established a method to generate libraries of genomic DNA fragments containing oxidatively modified bases by using specific monoclonal antibodies to immunoprecipitate enzyme-digested genome DNA. We applied this technique to two different base modifications, 8-hydroxyguanine and 1,N6-propanoadenine (acrotein-Ade), in a ferric nitrilotriacetate-induced murine renal carcinogenesis model. Renal cortical genomic DNA derived from 10- to 12-week-old male C57BL/6 mice, of untreated control or 6 hours after intraperitoneal injection of 3 mg iron/kg ferric nitrilotriacetate, was enzyme digested, immunoprecipitated, cloned, and mapped to each chromosome. The results revealed that distribution of the two modified bases was not random but differed in terms of chromosomes, gene size, and expression, which could be partially explained by chromosomal territory. In the wild-type mice, low GC content areas were more likely to harbor the two modified bases. Knockout of OGG1, a repair enzyme for genomic 8-hydroxyguanine, increased the amounts of acrolein-Ade as determined by quantitative polymerase chain reaction analyses. This versatile technique would introduce a novel research area as a high-throughput screening method for critical genomic loci under oxidative stress.
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